Anti-sulfoglucuronyl paragloboside IgM antibodies in amyotrophic lateral sclerosis

Amena Ben Younes-Chennoufi, Anne Rozier, Michel Dib, Pierre Bouche, lucette Lacomblez, Nina Mombo, Gilbert Ben Simon, Robert K. Yu, nicole Baumann, Vincent Meininger

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18 Scopus citations

Abstract

We report here our results on IgM anti-sulfated glucuronyl paragloboside (SGPG) antibodies in sera from patients with amyotrophic lateral sclerosis (ALS). Studies by enzyme linked immunosorbent assay on 72 ALS sera showed IgM polyclonal reactivity towards SGPG in 25 cases. The titer was high in 16 cases. Thin-layer chromatography immuno-overlay showed that reactivity with SGPG was associated to reactivity towards GM1 in five cases and to GM1 and GD1b in one case. Anti-SGPG reactivity was not found in controls and in multifocal motor neuropathy with conduction blocks, in contrast to anti-GM1 antibodies. The presence of anti-SGPG antibodies in ALS patients sera raise again the question of autoimmunity in this pathology.

Original languageEnglish (US)
Pages (from-to)111-115
Number of pages5
JournalJournal of Neuroimmunology
Volume57
Issue number1-2
DOIs
StatePublished - Mar 1995
Externally publishedYes

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Keywords

  • Amyotrophic lateral sclerosis
  • IgM antibodies
  • Sulfated glucuronyl paragloboside

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Younes-Chennoufi, A. B., Rozier, A., Dib, M., Bouche, P., Lacomblez, L., Mombo, N., Simon, G. B., Yu, R. K., Baumann, N., & Meininger, V. (1995). Anti-sulfoglucuronyl paragloboside IgM antibodies in amyotrophic lateral sclerosis. Journal of Neuroimmunology, 57(1-2), 111-115. https://doi.org/10.1016/0165-5728(94)00169-O