Antibiotic Prescribing in Outpatient Children: A Cohort From a Clinical Data Warehouse

Leslie Grammatico-Guillon, Kimberly Shea, S. Reza Jafarzadeh, Ingrid Camelo, Zoha Maakaroun-Vermesse, Marisol Figueira, William G. Adams, Steve Pelton

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Aim. To characterize antibiotic (ab) prescriptions in children. Methods. Evaluation of outpatient ab prescriptions in a 3-year cohort of children in primary care using a data warehouse (Massachusetts Health Disparities Repository) by comorbid conditions, demographics, and clinical indication. Results. A total of 15 208 children with nearly 120 000 outpatient visits were included. About one third had a comorbid condition (most commonly asthma). Among the 30 000 ab prescriptions, first-line penicillins and macrolides represented the most frequent ab (70%), followed by cephalosporins (16%). Comorbid children had 54.3 ab prescriptions/100 child-years versus 38.8 in children without comorbidity; ab prescription was higher in urinary tract infections (>60% of episodes), otitis, lower respiratory tract infections (>50%), especially in comorbid children and children under 2 year old. Ab prescriptions were significantly associated with younger age, emergency room visit, comorbid children, and acute infections. Discussion. A clinical data warehouse could help in designing appropriate antimicrobial stewardship programs and represent a potential assessment tool.

Original languageEnglish (US)
Pages (from-to)681-690
Number of pages10
JournalClinical Pediatrics
Issue number6
StatePublished - Jun 1 2019
Externally publishedYes


  • antibiotherapy
  • data warehouse
  • pediatric
  • primary care

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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