TY - JOUR
T1 - Antibiotic treatment of Lyme disease
T2 - Current recommendations by stage and extent of infection
AU - Rahn, Daniel Wallace
PY - 1992/1/1
Y1 - 1992/1/1
N2 - Much has been learned about Lyme disease over the past several years, but much remains to be learned. Careful clinical observation has led to elucidation of the natural history of this disease, and further clinical observations are needed to unravel the remaining areas of uncertainty. It is by no means clear that all the symptoms attributed to Lyme disease today actually represent true manifestations of Borrelia burgdorferi infection or that patients with well-documented Lyme disease whose symptoms do not respond to antibiotic therapy have persistent infection. Immunologically mediated mechanisms may be responsible for the chronic disease manifestations that seem so resistant to antibiotics. Uncovering answers to these questions requires the close collaboration of astute practicing physicians and biomedical scientists working together for their patients' benefit.
AB - Much has been learned about Lyme disease over the past several years, but much remains to be learned. Careful clinical observation has led to elucidation of the natural history of this disease, and further clinical observations are needed to unravel the remaining areas of uncertainty. It is by no means clear that all the symptoms attributed to Lyme disease today actually represent true manifestations of Borrelia burgdorferi infection or that patients with well-documented Lyme disease whose symptoms do not respond to antibiotic therapy have persistent infection. Immunologically mediated mechanisms may be responsible for the chronic disease manifestations that seem so resistant to antibiotics. Uncovering answers to these questions requires the close collaboration of astute practicing physicians and biomedical scientists working together for their patients' benefit.
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U2 - 10.1080/00325481.1992.11701343
DO - 10.1080/00325481.1992.11701343
M3 - Review article
C2 - 1589368
AN - SCOPUS:0026625633
SN - 0032-5481
VL - 91
SP - 57
EP - 64
JO - Postgraduate Medicine
JF - Postgraduate Medicine
IS - 7
ER -