Antibodies to glycoconjugates in human motor neuron disease

Norman Latov, Arthur P. Hays, Robert K Yu, Hiroaki Ito, Florian P. Thomas

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

IgM monoclonal gammopathy has been reported in some patients with motor neuron disease. The monoclonal IgMs in several of the patients bind to the carbohydrate epitope Gal (β1-3) GalNAc, which is shared by gangliosides GM1 and GD1b and glycoproteins in the nervous system and crossreacted with Gal (β1-3) G1cNAc. They also immunostain spinal cord and gray matter and presynaptic terminals of motor neurons at the neuromuscular junction. The role and mechanisms of action of these antibodies in motor neuron disease is under investigation.

Original languageEnglish (US)
Pages (from-to)181-187
Number of pages7
JournalNeurochemical Pathology
Volume8
Issue number3
DOIs
StatePublished - Jun 1 1988
Externally publishedYes

Keywords

  • Motor neurons, degeneration of
  • and gangliosides
  • autoimmune mechanisms
  • glycolipids
  • monoclonal antibodies

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology

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