Antibodies to hepatitis B surface antigen potentiate the response of human T lymphocyte clones to the same antigen

Esteban Celis, Tse Wen Chang

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Human T-helper lymphocyte clones specific for hepatitis B virus surface antigen (HBsAg) proliferate on stimulation with HBsAg in vitro. Antibodies specific for HBsAg, but no other antibodies, augment this proliferative response. In the presence of antibodies to HBsAg, the maximum response could be achieved at HBsAg concentrations that were 1 percent of those required in the absence of the antibodies. These findings suggest that antigen-specific antibodies exert regulatory controls on T cells that recognize the same antigens.

Original languageEnglish (US)
Pages (from-to)297-299
Number of pages3
JournalScience
Volume224
Issue number4646
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

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Hepatitis B Surface Antigens
Clone Cells
T-Lymphocytes
Antigens
Hepatitis B virus
Antibodies
Helper-Inducer T-Lymphocytes

ASJC Scopus subject areas

  • General

Cite this

Antibodies to hepatitis B surface antigen potentiate the response of human T lymphocyte clones to the same antigen. / Celis, Esteban; Chang, Tse Wen.

In: Science, Vol. 224, No. 4646, 01.01.1984, p. 297-299.

Research output: Contribution to journalArticle

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