Antibodies to low-incidence antigens and elimination of the antihuman globulin phase of the crossmatch - Case report

Anti Wra

Scott C Wise, P. J. Larson, L. O. Cook

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

An antibody to low-incidence antigen was identified in the serum of a nontransfused male patient. The antibody was subsequently identified as anti- Wra and was only detectable at the antihuman globulin (AHG) phase of the crossmatch. Instances of severe hemolytic transfusion reactions have been reported following the transfusion of red blood cells containing low- incidence antigens in patients with antibodies directed toward these antigens (e.g., anti Wr3 -Cob, -Jsa, etc.). Elimination of the AHG phase of the crossmatch can result in either risks or benefits. Since patients seen at this facility primarily have been multitransfused or are multiparous females, the AHG phase of the crossmatch has been maintained.

Original languageEnglish (US)
Pages (from-to)20-22
Number of pages3
JournalImmunohematology
Volume13
Issue number1
StatePublished - Jan 1 1997

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Globulins
Antigens
Antibodies
Incidence
Erythrocyte Transfusion
Serum

ASJC Scopus subject areas

  • Immunology
  • Hematology

Cite this

Antibodies to low-incidence antigens and elimination of the antihuman globulin phase of the crossmatch - Case report : Anti Wra. / Wise, Scott C; Larson, P. J.; Cook, L. O.

In: Immunohematology, Vol. 13, No. 1, 01.01.1997, p. 20-22.

Research output: Contribution to journalArticle

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