Antibody response to monovalent A/New Jersey/8/76 influenza vaccine in pregnant women

D. L. Murray, D. T. Imagawa, D. M. Okada, J. W. St. Geme

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The decision to implement a mass immunization program with A/New Jersey/8/76 (Hsw1N1) influenza vaccine provided a unique opportunity to evaluate immunological responses during pregnancy. Fifty-nine pregnant and 27 nonpregnant women participated in this study. Influenza virus hemagglutination-inhibition antibody titers were determined to A/New Jersey/8/76 (Hsw1N1), A/Japan/305/57 (H2N2), and A/Hong Kong/8/68 (H3N2) before and after a single dose of monovalent (200 chick cell agglutination units) influenza A/New Jersey/8/76 (Hsw1N1) vaccine. The difference in titers between pregnant and nonpregnant women was insignificant. Treatment of the sera with 2-mercaptoethanol disclosed a similar immunoglobulin M response to the vaccine in both groups. The mean fold rise in heterologous antibody titer was similar in pregnant and nonpregnant women. This study demonstrated that pregnant women were able to respond to an original myxovirus antigen, influenza A/New Jersey/8/76, in a manner equivalent to nonpregnant, age-matched controls.

Original languageEnglish (US)
Pages (from-to)184-187
Number of pages4
JournalJournal of Clinical Microbiology
Volume10
Issue number2
StatePublished - Dec 1 1979

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Influenza Vaccines
Antibody Formation
Pregnant Women
Orthomyxoviridae
Human Influenza
Vaccines
Heterophile Antibodies
Mass Vaccination
Immunization Programs
Mercaptoethanol
Agglutination
Hemagglutination
Hong Kong
Immunoglobulin M
Japan
Antigens
Pregnancy
Antibodies
Serum
Therapeutics

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Murray, D. L., Imagawa, D. T., Okada, D. M., & St. Geme, J. W. (1979). Antibody response to monovalent A/New Jersey/8/76 influenza vaccine in pregnant women. Journal of Clinical Microbiology, 10(2), 184-187.

Antibody response to monovalent A/New Jersey/8/76 influenza vaccine in pregnant women. / Murray, D. L.; Imagawa, D. T.; Okada, D. M.; St. Geme, J. W.

In: Journal of Clinical Microbiology, Vol. 10, No. 2, 01.12.1979, p. 184-187.

Research output: Contribution to journalArticle

Murray, DL, Imagawa, DT, Okada, DM & St. Geme, JW 1979, 'Antibody response to monovalent A/New Jersey/8/76 influenza vaccine in pregnant women', Journal of Clinical Microbiology, vol. 10, no. 2, pp. 184-187.
Murray, D. L. ; Imagawa, D. T. ; Okada, D. M. ; St. Geme, J. W. / Antibody response to monovalent A/New Jersey/8/76 influenza vaccine in pregnant women. In: Journal of Clinical Microbiology. 1979 ; Vol. 10, No. 2. pp. 184-187.
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