Anticancer agent xanthohumol inhibits IL-2 induced signaling pathways involved in T cell proliferation

Yongbo Liu, Xiaohua Gao, Dorrah Deeb, Ali Syed Arbab, Scott A. Dulchavsky, Subhash C. Gauta

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Xanthohumol (XN), a prenylated chalcone present in hops exhibits anti-inflammatory, antioxidant and anticancer activity. In the present study we show that XN inhibits the proliferation of mouse lymphoma cells and IL-2 induced proliferation and cell cycle progression in mouse splenic T cells. The suppression of T cell proliferation by XN was due to the inhibition of IL-2 induced Janus kinase/signal transducers and activators of transcription (Jak/STAT) and extracellular signal-regulated kinase 1 and 2 (Erk1/2) signaling pathways. XN also inhibited proliferation-related cellular proteins such as c-Myc, c-Fos and NF-κB and cyclin D1. Thus, understanding of IL-2 induced cell signaling pathways in normal T cells, which are constitutively turned on in T cell lymphomas may facilitate development of XN for the treatment of hematologic cancers.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of Experimental Therapeutics and Oncology
Volume10
Issue number1
StatePublished - Aug 3 2012
Externally publishedYes

Fingerprint

Antineoplastic Agents
Interleukin-2
Cell Proliferation
T-Lymphocytes
Janus Kinases
Chalcone
Humulus
Mitogen-Activated Protein Kinase 3
T-Cell Lymphoma
Mitogen-Activated Protein Kinase 1
Cyclin D1
Transducers
Lymphoma
Cell Cycle
Anti-Inflammatory Agents
Antioxidants
xanthohumol
Neoplasms
Proteins

Keywords

  • Erk1/2
  • IL-2
  • Jak/STAT
  • Proliferation
  • Xanthohumol

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Cancer Research

Cite this

Anticancer agent xanthohumol inhibits IL-2 induced signaling pathways involved in T cell proliferation. / Liu, Yongbo; Gao, Xiaohua; Deeb, Dorrah; Arbab, Ali Syed; Dulchavsky, Scott A.; Gauta, Subhash C.

In: Journal of Experimental Therapeutics and Oncology, Vol. 10, No. 1, 03.08.2012, p. 1-8.

Research output: Contribution to journalArticle

Liu, Yongbo ; Gao, Xiaohua ; Deeb, Dorrah ; Arbab, Ali Syed ; Dulchavsky, Scott A. ; Gauta, Subhash C. / Anticancer agent xanthohumol inhibits IL-2 induced signaling pathways involved in T cell proliferation. In: Journal of Experimental Therapeutics and Oncology. 2012 ; Vol. 10, No. 1. pp. 1-8.
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