Anticancer agent xanthohumol inhibits IL-2 induced signaling pathways involved in T cell proliferation

Yongbo Liu, Xiaohua Gao, Dorrah Deeb, Ali S. Arbab, Scott A. Dulchavsky, Subhash C. Gauta

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Xanthohumol (XN), a prenylated chalcone present in hops exhibits anti-inflammatory, antioxidant and anticancer activity. In the present study we show that XN inhibits the proliferation of mouse lymphoma cells and IL-2 induced proliferation and cell cycle progression in mouse splenic T cells. The suppression of T cell proliferation by XN was due to the inhibition of IL-2 induced Janus kinase/signal transducers and activators of transcription (Jak/STAT) and extracellular signal-regulated kinase 1 and 2 (Erk1/2) signaling pathways. XN also inhibited proliferation-related cellular proteins such as c-Myc, c-Fos and NF-κB and cyclin D1. Thus, understanding of IL-2 induced cell signaling pathways in normal T cells, which are constitutively turned on in T cell lymphomas may facilitate development of XN for the treatment of hematologic cancers.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of Experimental Therapeutics and Oncology
Volume10
Issue number1
StatePublished - Aug 3 2012
Externally publishedYes

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Keywords

  • Erk1/2
  • IL-2
  • Jak/STAT
  • Proliferation
  • Xanthohumol

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Cancer Research

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