Antimicrobial activity of a quaternary ammonium methacryloxy silicate-containing acrylic resin: A randomised clinical trial

Si Ying Liu, Lige Tonggu, Li Na Niu, Shi Qiang Gong, Bing Fan, Liguo Wang, Ji Hong Zhao, Cui Huang, David Henry Pashley, Franklin Chi Meng Tay

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Quaternary ammonium methacryloxy silicate (QAMS)-containing acrylic resin demonstrated contact-killing antimicrobial ability in vitro after three months of water storage. The objective of the present double-blind randomised clinical trial was to determine the in vivo antimicrobial efficacy of QAMS-containing orthodontic acrylic by using custom-made removable retainers that were worn intraorally by 32 human subjects to create 48-hour multi-species plaque biofilms, using a split-mouth study design. Two control QAMS-free acrylic disks were inserted into the wells on one side of an orthodontic retainer, and two experimental QAMS-containing acrylic disks were inserted into the wells on the other side of the same retainer. After 48 hours, the disks were retrieved and examined for microbial vitality using confocal laser scanning microscopy. No harm to the oral mucosa or systemic health occurred. In the absence of carry-across effect and allocation bias (disks inserted in the left or right side of retainer), significant difference was identified between the percentage kill in the biovolume of QAMS-free control disks (3.73 ± 2.11%) and QAMS-containing experimental disks (33.94 ± 23.88%) retrieved from the subjects (P ≤ 0.001). The results validated that the QAMS-containing acrylic exhibits favourable antimicrobial activity against plaque biofilms in vivo. The QAMS-containing acrylic may also be used for fabricating removable acrylic dentures.

Original languageEnglish (US)
Article number21882
JournalScientific Reports
Volume6
DOIs
StatePublished - Feb 23 2016

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Acrylic Resins
Silicates
Ammonium Compounds
Randomized Controlled Trials
Biofilms
Orthodontic Retainers
Dentures
Mouth Mucosa
Orthodontics
Confocal Microscopy
Mouth
Water
Health

ASJC Scopus subject areas

  • General

Cite this

Antimicrobial activity of a quaternary ammonium methacryloxy silicate-containing acrylic resin : A randomised clinical trial. / Liu, Si Ying; Tonggu, Lige; Niu, Li Na; Gong, Shi Qiang; Fan, Bing; Wang, Liguo; Zhao, Ji Hong; Huang, Cui; Pashley, David Henry; Tay, Franklin Chi Meng.

In: Scientific Reports, Vol. 6, 21882, 23.02.2016.

Research output: Contribution to journalArticle

Liu, Si Ying ; Tonggu, Lige ; Niu, Li Na ; Gong, Shi Qiang ; Fan, Bing ; Wang, Liguo ; Zhao, Ji Hong ; Huang, Cui ; Pashley, David Henry ; Tay, Franklin Chi Meng. / Antimicrobial activity of a quaternary ammonium methacryloxy silicate-containing acrylic resin : A randomised clinical trial. In: Scientific Reports. 2016 ; Vol. 6.
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