Actividades antioxidante y neutralizante de radicales libres del extracto metanólico de sida rhomboidea. Roxb determinadas por diferentes modelos in vitro

Translated title of the contribution: Antioxidant and free radical scavenging activity of sida rhomboidea. Roxb methanolic extract determined using different in vitro models

Menaka C. Thounaojam, Ravirajsinh N. Jadeja, Ranjitsinh V. Devkar, A. V. Ramachandran

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Antioxidant potential of Sida rhomboidea.Roxb methanol extract (MESR) was evaluated using in vitro models such as lipid peroxidation, metal chelation and reducing potential. Its free radical scavenging ability was also examined using in vitro assays for 1, 1-diphenyl-2-picryl-hydrazil (DPPH,) superoxide (.O2), hydrogen peroxide (H2O2), nitric oxide (NO.) and hydroxyl radical (HO.) radical scavenging. MESR recorded dose dependent effect on inhibition of lipid perodixation (IC50= 92.15±1.21μg/ml), effective metal chelation (IC50=65.69±1.22μg/ml) and higher reducing potential (ODmax=1.20±0.27). MESR could efficiently scavenged DPPH (IC50=63.23±1.59μg/ml), .O2 (IC50=142.36±2.59μg/ml), H2O2 (IC50=125.96±3.00 μg/ml), NO. (IC50=85.36±2.01 μg/ml) and HO. (IC50=90.45±1.88 μg/ml) radicals in a dose dependent manner. Results obtained herein can be attributed to the presence of polyphenols (35.60±1.20 mg/ml gallic acid equivalent-polyphenols), flavanoids (26.94±0.94 mg/ml quercetin equivalent-flavanoids) and ascorbic acid (28.71±1.14 mg/ml ascorbic acid) in MESR. These observations suggest antioxidant and free radical scavenging potentials of MESR that adds a new dimension to its already established therapeutic uses.

Original languageSpanish
Pages (from-to)191-198
Number of pages8
JournalBoletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
Volume9
Issue number3
Publication statusPublished - May 1 2010
Externally publishedYes

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Keywords

  • Antioxidant
  • Free radical
  • Sida rhomboidea roxb

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

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