Antioxidant effects of statins

Lynn L. Stoll, Michael L. McCormick, Gerene M. Denning, Neal L. Weintraub

Research output: Contribution to journalReview article

95 Scopus citations

Abstract

Statins, a group of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, are widely used in clinical practice for their efficacy in producing significant reductions in plasma cholesterol and LDL cholesterol and in reducing morbidity and mortality from cardiovascular disease. However, several large clinical trials have suggested that the cholesterol-lowering effects of statins may not completely account for the reduced incidence of cardiovascular disease seen in patients receiving statin therapy. A number of recent reports have shown that statins may also have important antiinflammatory effects, in addition to their effects on plasma lipids. Since inflammation is closely linked to the production of reactive oxygen species (ROS), the molecular basis of the observed antiinflammatory effects of statins may relate to their ability block the production and/or activity of ROS. In this review, we will discuss both the inhibition of ROS generation by statins, through interference with NAD(P)H oxidase expression and activity, and the actions of statins that serve to blunt the damaging effects of these radicals, including effects on antioxidant enzymes, lipid peroxidation, LDL cholesterol oxidation and nitric oxide synthase. These antioxidant effects of statins likely contribute to their clinical efficacy in treating cardiovascular disease as well as other chronic conditions associated with increased oxidative stress in humans.

Original languageEnglish (US)
Pages (from-to)975-989
Number of pages15
JournalDrugs of Today
Volume40
Issue number12
DOIs
StatePublished - Dec 1 2004
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Stoll, L. L., McCormick, M. L., Denning, G. M., & Weintraub, N. L. (2004). Antioxidant effects of statins. Drugs of Today, 40(12), 975-989. https://doi.org/10.1358/dot.2004.40.12.872573