Antipsychotic Drugs

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

All antipsychotic drugs decrease dopamine neurotransmission. The conventional neuroleptic drugs block dopamine D2 receptors, leading to a gradual reduction of acute psychotic features and the prevention of relapse; they produce coarse neurological side effects at excessive doses. Clozapine was the first atypical antipsychotic in that it did not produce neurological side effects; it also produced greater therapeutic benefit than did the conventional neuroleptics. The newer atypical antipsychotic drugs add antagonism at type 2 serotonin receptors to D2 antagonism, and produce less neurological side effects; however, some of these drugs produce substantial weight gain, and elevations in lipids and insulin resistance.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd.
Pages487-492
Number of pages6
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

Keywords

  • Antipsychotic drugsAripiprazoleAtypical antipsychotic drugsChlorpromazineClozapineNeurolepticsOlanzapinePerphenazinePsychosisQ uetiapineRisperidoneSchizophreniaZiprasidone

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Antipsychotic Drugs'. Together they form a unique fingerprint.

  • Cite this

    McEvoy, J. P. (2009). Antipsychotic Drugs. In Encyclopedia of Neuroscience (pp. 487-492). Elsevier Ltd.. https://doi.org/10.1016/B978-008045046-9.00375-2