Antipsychotic Drugs

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

All antipsychotic drugs decrease dopamine neurotransmission. The conventional neuroleptic drugs block dopamine D2 receptors, leading to a gradual reduction of acute psychotic features and the prevention of relapse; they produce coarse neurological side effects at excessive doses. Clozapine was the first atypical antipsychotic in that it did not produce neurological side effects; it also produced greater therapeutic benefit than did the conventional neuroleptics. The newer atypical antipsychotic drugs add antagonism at type 2 serotonin receptors to D2 antagonism, and produce less neurological side effects; however, some of these drugs produce substantial weight gain, and elevations in lipids and insulin resistance.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd.
Pages487-492
Number of pages6
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

Fingerprint

Antipsychotic Agents
Drug Antagonism
Serotonin 5-HT2 Receptors
Dopamine D2 Receptors
Clozapine
Secondary Prevention
Synaptic Transmission
Weight Gain
Insulin Resistance
Dopamine
Lipids
Pharmaceutical Preparations
Therapeutics

Keywords

  • Antipsychotic drugsAripiprazoleAtypical antipsychotic drugsChlorpromazineClozapineNeurolepticsOlanzapinePerphenazinePsychosisQ uetiapineRisperidoneSchizophreniaZiprasidone

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

McEvoy, J. P. (2009). Antipsychotic Drugs. In Encyclopedia of Neuroscience (pp. 487-492). Elsevier Ltd.. https://doi.org/10.1016/B978-008045046-9.00375-2

Antipsychotic Drugs. / McEvoy, Joseph Patrick.

Encyclopedia of Neuroscience. Elsevier Ltd., 2009. p. 487-492.

Research output: Chapter in Book/Report/Conference proceedingChapter

McEvoy, JP 2009, Antipsychotic Drugs. in Encyclopedia of Neuroscience. Elsevier Ltd., pp. 487-492. https://doi.org/10.1016/B978-008045046-9.00375-2
McEvoy JP. Antipsychotic Drugs. In Encyclopedia of Neuroscience. Elsevier Ltd. 2009. p. 487-492 https://doi.org/10.1016/B978-008045046-9.00375-2
McEvoy, Joseph Patrick. / Antipsychotic Drugs. Encyclopedia of Neuroscience. Elsevier Ltd., 2009. pp. 487-492
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