Antithrombotic activity of Formononetin sodium and its mechanism

Yan Jun Wan, Peng Wei Zhuang, Yan Jun Zhang

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Objective: To investigate the effect of formononetin sodium on thrombus formation and its mechanism. Methods: The inhibitory action of formononetin sodium on the thrombus formation was investigated by the model of ferric chloride-induced carotid artery thrombosis in rats. The antithrombotic mechanism was investigated by platelet aggregation and coagulation tests. Results: Formononetin sodium at high and middle dose could inhibit arterial thrombus formation, ADP, and thrombin-induced platelet aggregation in rats, while prolong bleeding time and APTT in mice (P<0.01). Conclusion: Formononetin sodium has anti-thrombosis effect, and its mechanism may correlate with inhibition of ADP, thrombin-induced platelet aggregation and reduction of the function of endogenous coagulation pathway.

Original languageEnglish (US)
Pages (from-to)1355-1358
Number of pages4
JournalChinese Journal of New Drugs
Volume25
Issue number12
StatePublished - Jun 30 2016

Keywords

  • Formononetin sodium
  • Platelet aggregation
  • Thrombus formation

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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    Wan, Y. J., Zhuang, P. W., & Zhang, Y. J. (2016). Antithrombotic activity of Formononetin sodium and its mechanism. Chinese Journal of New Drugs, 25(12), 1355-1358.