Antitumor constituents of Polyporus giganteus

Byong Kak Kim, Mi Ja Shim, Ha Won Kim, Myoung Sik Woo, Eung Chil Choi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To investigate antitumor constituents of higher fungi, the carpophores of Polyporus giganteus Pers. ex. Fr. (81 g, dry weight) which were collected in Indiana, U.S.A. were examined for antitumor activity. Two protein-bound polysaccharide fractions (I and II) were prepared from the hot water extract and one fraction (III) from the 0.1 N NaOH extract of the carpophores. The antitumor effect of each fraction was tested against sarcoma 180 implanted subcutaneously in female ICR mice. Of three fractions, Fraction II showed 85.2% inhibition ratio at the dose of 20 mg/kg/day for 10 days and was named gigantan. Gigantan was found to contain 59% polysaccharide and 27% protein. Its polysaccharide moiety was a heteroglycan that consisted of mainly glucose (89.3%), galactose (7.7%), manose (2.0%) and fructose (1.0%).

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
JournalArchives of Pharmacal Research
Volume10
Issue number3
DOIs
StatePublished - Sep 1 1987
Externally publishedYes

Fingerprint

Polyporus
Polysaccharides
Sarcoma 180
Inbred ICR Mouse
Fructose
Fungi
Galactose
Proteins
Weights and Measures
Glucose
Water

Keywords

  • Antitumor activity
  • Basidiomycete
  • Gigantan
  • Heteroglycan
  • Polyporaceae
  • Polyporus giganteus

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

Cite this

Antitumor constituents of Polyporus giganteus. / Kim, Byong Kak; Shim, Mi Ja; Kim, Ha Won; Woo, Myoung Sik; Choi, Eung Chil.

In: Archives of Pharmacal Research, Vol. 10, No. 3, 01.09.1987, p. 179-183.

Research output: Contribution to journalArticle

Kim, BK, Shim, MJ, Kim, HW, Woo, MS & Choi, EC 1987, 'Antitumor constituents of Polyporus giganteus', Archives of Pharmacal Research, vol. 10, no. 3, pp. 179-183. https://doi.org/10.1007/BF02861910
Kim, Byong Kak ; Shim, Mi Ja ; Kim, Ha Won ; Woo, Myoung Sik ; Choi, Eung Chil. / Antitumor constituents of Polyporus giganteus. In: Archives of Pharmacal Research. 1987 ; Vol. 10, No. 3. pp. 179-183.
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