Antitumor constituents of Polyporus giganteus

Byong Kak Kim, Mi Ja Shim, Ha Won Kim, Myoung Sik Woo, Eung Chil Choi

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

To investigate antitumor constituents of higher fungi, the carpophores of Polyporus giganteus Pers. ex. Fr. (81 g, dry weight) which were collected in Indiana, U.S.A. were examined for antitumor activity. Two protein-bound polysaccharide fractions (I and II) were prepared from the hot water extract and one fraction (III) from the 0.1 N NaOH extract of the carpophores. The antitumor effect of each fraction was tested against sarcoma 180 implanted subcutaneously in female ICR mice. Of three fractions, Fraction II showed 85.2% inhibition ratio at the dose of 20 mg/kg/day for 10 days and was named gigantan. Gigantan was found to contain 59% polysaccharide and 27% protein. Its polysaccharide moiety was a heteroglycan that consisted of mainly glucose (89.3%), galactose (7.7%), manose (2.0%) and fructose (1.0%).

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
JournalArchives of Pharmacal Research
Volume10
Issue number3
DOIs
StatePublished - Sep 1 1987
Externally publishedYes

Keywords

  • Antitumor activity
  • Basidiomycete
  • Gigantan
  • Heteroglycan
  • Polyporaceae
  • Polyporus giganteus

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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