Anxiety, depressive, and posttraumatic stress disorders among mothers of pediatric survivors of hematopoietic stem cell transplantation

Sharon Manne, Katherine DuHamel, Jamie Ostroff, Susan Parsons, D. Richard Martini, Sharon E. Williams, Laura Mee, Sandra Griffin Bishop Sexson, Jane Austin, Joanne Difede, Christine Rini, William H. Redd

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Objective. To examine the prevalence and predictors of anxiety, depression, and posttraumatic stress disorder among mothers of children who underwent hematopoietic stem cell transplantation (HSCT). Methods. A total of 111 mothers of children who survived HSCT completed self-report measures of psychological functioning at the time of HSCT and self-report measures and a structured psychiatric interview 18 months after HSCT. Demographic data and medical data were also collected. Results. Approximately 20% of mothers had clinically significant distress reactions. When subthreshold posttraumatic stress disorder was included, nearly one third of mothers met the criterion for persistent distress. Mothers with 1 of the 4 psychiatric diagnoses reported a significantly lower quality of life, suggesting that the diagnoses had an impact on their general quality of life. Mothers who had 1 of the 4 diagnoses at 18 months were younger and had higher anxiety and depressive symptoms at the time of HSCT. Conclusions. A subset of mothers of children who survive HSCT may require psychological intervention. Mothers who are most at risk are younger and evidence anxiety and depressive symptoms at the time of transplantation.

Original languageEnglish (US)
Pages (from-to)1700-1708
Number of pages9
JournalPediatrics
Volume113
Issue number6 I
DOIs
StatePublished - Jun 1 2004
Externally publishedYes

Fingerprint

Hematopoietic Stem Cell Transplantation
Post-Traumatic Stress Disorders
Survivors
Anxiety
Mothers
Pediatrics
Depression
Self Report
Quality of Life
Psychology
Mental Disorders
Psychiatry
Transplantation
Demography
Interviews

Keywords

  • Childhood cancer survivors
  • Maternal distress
  • Stem cell transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Manne, S., DuHamel, K., Ostroff, J., Parsons, S., Martini, D. R., Williams, S. E., ... Redd, W. H. (2004). Anxiety, depressive, and posttraumatic stress disorders among mothers of pediatric survivors of hematopoietic stem cell transplantation. Pediatrics, 113(6 I), 1700-1708. https://doi.org/10.1542/peds.113.6.1700

Anxiety, depressive, and posttraumatic stress disorders among mothers of pediatric survivors of hematopoietic stem cell transplantation. / Manne, Sharon; DuHamel, Katherine; Ostroff, Jamie; Parsons, Susan; Martini, D. Richard; Williams, Sharon E.; Mee, Laura; Sexson, Sandra Griffin Bishop; Austin, Jane; Difede, Joanne; Rini, Christine; Redd, William H.

In: Pediatrics, Vol. 113, No. 6 I, 01.06.2004, p. 1700-1708.

Research output: Contribution to journalArticle

Manne, S, DuHamel, K, Ostroff, J, Parsons, S, Martini, DR, Williams, SE, Mee, L, Sexson, SGB, Austin, J, Difede, J, Rini, C & Redd, WH 2004, 'Anxiety, depressive, and posttraumatic stress disorders among mothers of pediatric survivors of hematopoietic stem cell transplantation', Pediatrics, vol. 113, no. 6 I, pp. 1700-1708. https://doi.org/10.1542/peds.113.6.1700
Manne, Sharon ; DuHamel, Katherine ; Ostroff, Jamie ; Parsons, Susan ; Martini, D. Richard ; Williams, Sharon E. ; Mee, Laura ; Sexson, Sandra Griffin Bishop ; Austin, Jane ; Difede, Joanne ; Rini, Christine ; Redd, William H. / Anxiety, depressive, and posttraumatic stress disorders among mothers of pediatric survivors of hematopoietic stem cell transplantation. In: Pediatrics. 2004 ; Vol. 113, No. 6 I. pp. 1700-1708.
@article{4f7ab3c734f042ac9c73099e16a22d72,
title = "Anxiety, depressive, and posttraumatic stress disorders among mothers of pediatric survivors of hematopoietic stem cell transplantation",
abstract = "Objective. To examine the prevalence and predictors of anxiety, depression, and posttraumatic stress disorder among mothers of children who underwent hematopoietic stem cell transplantation (HSCT). Methods. A total of 111 mothers of children who survived HSCT completed self-report measures of psychological functioning at the time of HSCT and self-report measures and a structured psychiatric interview 18 months after HSCT. Demographic data and medical data were also collected. Results. Approximately 20{\%} of mothers had clinically significant distress reactions. When subthreshold posttraumatic stress disorder was included, nearly one third of mothers met the criterion for persistent distress. Mothers with 1 of the 4 psychiatric diagnoses reported a significantly lower quality of life, suggesting that the diagnoses had an impact on their general quality of life. Mothers who had 1 of the 4 diagnoses at 18 months were younger and had higher anxiety and depressive symptoms at the time of HSCT. Conclusions. A subset of mothers of children who survive HSCT may require psychological intervention. Mothers who are most at risk are younger and evidence anxiety and depressive symptoms at the time of transplantation.",
keywords = "Childhood cancer survivors, Maternal distress, Stem cell transplantation",
author = "Sharon Manne and Katherine DuHamel and Jamie Ostroff and Susan Parsons and Martini, {D. Richard} and Williams, {Sharon E.} and Laura Mee and Sexson, {Sandra Griffin Bishop} and Jane Austin and Joanne Difede and Christine Rini and Redd, {William H.}",
year = "2004",
month = "6",
day = "1",
doi = "10.1542/peds.113.6.1700",
language = "English (US)",
volume = "113",
pages = "1700--1708",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "6 I",

}

TY - JOUR

T1 - Anxiety, depressive, and posttraumatic stress disorders among mothers of pediatric survivors of hematopoietic stem cell transplantation

AU - Manne, Sharon

AU - DuHamel, Katherine

AU - Ostroff, Jamie

AU - Parsons, Susan

AU - Martini, D. Richard

AU - Williams, Sharon E.

AU - Mee, Laura

AU - Sexson, Sandra Griffin Bishop

AU - Austin, Jane

AU - Difede, Joanne

AU - Rini, Christine

AU - Redd, William H.

PY - 2004/6/1

Y1 - 2004/6/1

N2 - Objective. To examine the prevalence and predictors of anxiety, depression, and posttraumatic stress disorder among mothers of children who underwent hematopoietic stem cell transplantation (HSCT). Methods. A total of 111 mothers of children who survived HSCT completed self-report measures of psychological functioning at the time of HSCT and self-report measures and a structured psychiatric interview 18 months after HSCT. Demographic data and medical data were also collected. Results. Approximately 20% of mothers had clinically significant distress reactions. When subthreshold posttraumatic stress disorder was included, nearly one third of mothers met the criterion for persistent distress. Mothers with 1 of the 4 psychiatric diagnoses reported a significantly lower quality of life, suggesting that the diagnoses had an impact on their general quality of life. Mothers who had 1 of the 4 diagnoses at 18 months were younger and had higher anxiety and depressive symptoms at the time of HSCT. Conclusions. A subset of mothers of children who survive HSCT may require psychological intervention. Mothers who are most at risk are younger and evidence anxiety and depressive symptoms at the time of transplantation.

AB - Objective. To examine the prevalence and predictors of anxiety, depression, and posttraumatic stress disorder among mothers of children who underwent hematopoietic stem cell transplantation (HSCT). Methods. A total of 111 mothers of children who survived HSCT completed self-report measures of psychological functioning at the time of HSCT and self-report measures and a structured psychiatric interview 18 months after HSCT. Demographic data and medical data were also collected. Results. Approximately 20% of mothers had clinically significant distress reactions. When subthreshold posttraumatic stress disorder was included, nearly one third of mothers met the criterion for persistent distress. Mothers with 1 of the 4 psychiatric diagnoses reported a significantly lower quality of life, suggesting that the diagnoses had an impact on their general quality of life. Mothers who had 1 of the 4 diagnoses at 18 months were younger and had higher anxiety and depressive symptoms at the time of HSCT. Conclusions. A subset of mothers of children who survive HSCT may require psychological intervention. Mothers who are most at risk are younger and evidence anxiety and depressive symptoms at the time of transplantation.

KW - Childhood cancer survivors

KW - Maternal distress

KW - Stem cell transplantation

UR - http://www.scopus.com/inward/record.url?scp=2542637227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2542637227&partnerID=8YFLogxK

U2 - 10.1542/peds.113.6.1700

DO - 10.1542/peds.113.6.1700

M3 - Article

C2 - 15173494

AN - SCOPUS:2542637227

VL - 113

SP - 1700

EP - 1708

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 6 I

ER -