Aplysia mollusk-derived growth factor is a mitogen with adenosine deaminase activity and is expressed in the developing central nervous system

David Benjamin G. Akalal, Jane E. Bottenstein, Seung Hee Lee, Jin Hee Han, Deog Jin Chang, Bong Kiun Kaang, Gregg Thomas Nagle

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Mollusk-derived growth factor (MDGF), the first growth factor to be characterized in Aplysia, was purified and characterized and has both adenosine deaminase activity and stimulates cell proliferation in vitro. MDGF is structurally related to a new subfamily of adenosine deaminase-related growth factors that require enzymatic activity to stimulate cell proliferation, a unique property of known growth factors. We examined the expression of MDGF protein in the CNS since MDGF mRNA increased in the developing CNS, and recent data suggest that inosine is involved in neuronal reorganization and restoration of essential circuitry after CNS injury. MDGF levels transiently increased during embryonic and post-metamorphic development and in the developing CNS, but was undetectable in adult CNS. No effects on morphology or neurite extension of adult Aplysia neurons were observed.

Original languageEnglish (US)
Pages (from-to)228-236
Number of pages9
JournalMolecular Brain Research
Volume117
Issue number2
DOIs
StatePublished - Oct 7 2003
Externally publishedYes

Fingerprint

Aplysia
Adenosine Deaminase
Mitogens
Central Nervous System
Intercellular Signaling Peptides and Proteins
Cell Proliferation
Inosine
Neurites
mollusk-derived growth factor
Neurons
Messenger RNA
Wounds and Injuries
Proteins

Keywords

  • ADA
  • Adenosine deaminase-related growth factor
  • Aplysia
  • CECR1
  • Developing central nervous system
  • Insect-derived growth factor
  • MDGF
  • Neurotransmitters, modulators, transporters, and receptors
  • Transmitters in invertebrates

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Aplysia mollusk-derived growth factor is a mitogen with adenosine deaminase activity and is expressed in the developing central nervous system. / Akalal, David Benjamin G.; Bottenstein, Jane E.; Lee, Seung Hee; Han, Jin Hee; Chang, Deog Jin; Kaang, Bong Kiun; Nagle, Gregg Thomas.

In: Molecular Brain Research, Vol. 117, No. 2, 07.10.2003, p. 228-236.

Research output: Contribution to journalArticle

Akalal, David Benjamin G. ; Bottenstein, Jane E. ; Lee, Seung Hee ; Han, Jin Hee ; Chang, Deog Jin ; Kaang, Bong Kiun ; Nagle, Gregg Thomas. / Aplysia mollusk-derived growth factor is a mitogen with adenosine deaminase activity and is expressed in the developing central nervous system. In: Molecular Brain Research. 2003 ; Vol. 117, No. 2. pp. 228-236.
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AU - Lee, Seung Hee

AU - Han, Jin Hee

AU - Chang, Deog Jin

AU - Kaang, Bong Kiun

AU - Nagle, Gregg Thomas

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