Appearance of a nonfunctional isozyme of hepatic glycogen synthase in late gestation

Stephen Hsu, Stephen R. Jaspers, Betty B. Davis, Robert R. Cardell, Thomas B. Miller, Richard L. Drake

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Glycogen levels, glycogen synthase activities, and glycogen synthase protein levels were determined in liver tissues obtained from 14- to 19-day-old fetal mice, newborn mice, and adult mice. The results of these experiments demonstrate a significant increase in the quantity of hepatic glycogen synthase beginning at Day 17 of gestation and reaching adult levels at birth. However, during the same time period, there is a dramatic decrease in total glycogen synthase activity suggesting that the accumulating glycogen synthase molecules are unable to transfer UDP-glucose to glycogen. These inversely coordinated changes in the quantity and activity of glycogen synthase are consistent with the suggestion that glycogen synthesis in the near-term fetal mouse is being maintained by preexisting enzyme, while accumulating enzyme molecules may represent a quiescent isozyme.

Original languageEnglish (US)
Pages (from-to)152-156
Number of pages5
JournalArchives of Biochemistry and Biophysics
Volume281
Issue number1
DOIs
StatePublished - Aug 15 1990
Externally publishedYes

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Glycogen Synthase
Liver Glycogen
Isoenzymes
Pregnancy
Glycogen
Uridine Diphosphate Glucose
Molecules
Enzymes
Liver
Parturition
Tissue
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Appearance of a nonfunctional isozyme of hepatic glycogen synthase in late gestation. / Hsu, Stephen; Jaspers, Stephen R.; Davis, Betty B.; Cardell, Robert R.; Miller, Thomas B.; Drake, Richard L.

In: Archives of Biochemistry and Biophysics, Vol. 281, No. 1, 15.08.1990, p. 152-156.

Research output: Contribution to journalArticle

Hsu, Stephen ; Jaspers, Stephen R. ; Davis, Betty B. ; Cardell, Robert R. ; Miller, Thomas B. ; Drake, Richard L. / Appearance of a nonfunctional isozyme of hepatic glycogen synthase in late gestation. In: Archives of Biochemistry and Biophysics. 1990 ; Vol. 281, No. 1. pp. 152-156.
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