Application of measuring 99mTc-MAG3 plasma clearance based on one- compartment model (MPC method) to pediatric patients

Kiyoshi Koizumi, K. Higashida, Ali Syed Arbab, K. Toyama, T. Arai, T. Yoshitomi

Research output: Contribution to journalArticle

Abstract

Measurement of 99mTc-MAG3 plasma clearance based on 1-compartment model (MPC method) were applied to 12 pediatric patients and evaluated for the factors which might affect the calculated results. Depth correction is a critical factor for the measurement of renal uptake. Three different equations for estimating renal depth were compared with the real depth measured by ultrasonography. The equation proposed by K. Itoh was suitable though the equations by T. Ito and Raynaud were insufficient. Estimation of distribution volume, which is regarded as circulating plasma volume (CPV), is also critical for the calculation of MAG3 clearance by MPC method. Precisely, hematocrit measured by venous sampling and circulating blood volume (CBV) calculated as 7.5% of body weight are used for estimation of CPV. However, assumed CPV as 5% of body weight was acceptable if the hematocrit was not severely deviated from the normal value. Simplified MPC method utilizing two factors mentioned above gave a positive correlation with Russell's one point sampling method. In conclusion, MPC method is applicable for pediatric patients.

Original languageEnglish (US)
Pages (from-to)259-265
Number of pages7
JournalKakuigaku
Volume34
Issue number4
StatePublished - Jun 26 1997
Externally publishedYes

Fingerprint

Technetium Tc 99m Mertiatide
Pediatrics
Plasma Volume
Hematocrit
Body Weight
Kidney
Blood Volume
Ultrasonography
Reference Values

Keywords

  • Plasma clearance
  • Radionuclide renal study
  • Renal function
  • Tc-MAG3

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Application of measuring 99mTc-MAG3 plasma clearance based on one- compartment model (MPC method) to pediatric patients. / Koizumi, Kiyoshi; Higashida, K.; Arbab, Ali Syed; Toyama, K.; Arai, T.; Yoshitomi, T.

In: Kakuigaku, Vol. 34, No. 4, 26.06.1997, p. 259-265.

Research output: Contribution to journalArticle

Koizumi, K, Higashida, K, Arbab, AS, Toyama, K, Arai, T & Yoshitomi, T 1997, 'Application of measuring 99mTc-MAG3 plasma clearance based on one- compartment model (MPC method) to pediatric patients', Kakuigaku, vol. 34, no. 4, pp. 259-265.
Koizumi, Kiyoshi ; Higashida, K. ; Arbab, Ali Syed ; Toyama, K. ; Arai, T. ; Yoshitomi, T. / Application of measuring 99mTc-MAG3 plasma clearance based on one- compartment model (MPC method) to pediatric patients. In: Kakuigaku. 1997 ; Vol. 34, No. 4. pp. 259-265.
@article{45481ed8654d45efafead86b1f042301,
title = "Application of measuring 99mTc-MAG3 plasma clearance based on one- compartment model (MPC method) to pediatric patients",
abstract = "Measurement of 99mTc-MAG3 plasma clearance based on 1-compartment model (MPC method) were applied to 12 pediatric patients and evaluated for the factors which might affect the calculated results. Depth correction is a critical factor for the measurement of renal uptake. Three different equations for estimating renal depth were compared with the real depth measured by ultrasonography. The equation proposed by K. Itoh was suitable though the equations by T. Ito and Raynaud were insufficient. Estimation of distribution volume, which is regarded as circulating plasma volume (CPV), is also critical for the calculation of MAG3 clearance by MPC method. Precisely, hematocrit measured by venous sampling and circulating blood volume (CBV) calculated as 7.5{\%} of body weight are used for estimation of CPV. However, assumed CPV as 5{\%} of body weight was acceptable if the hematocrit was not severely deviated from the normal value. Simplified MPC method utilizing two factors mentioned above gave a positive correlation with Russell's one point sampling method. In conclusion, MPC method is applicable for pediatric patients.",
keywords = "Plasma clearance, Radionuclide renal study, Renal function, Tc-MAG3",
author = "Kiyoshi Koizumi and K. Higashida and Arbab, {Ali Syed} and K. Toyama and T. Arai and T. Yoshitomi",
year = "1997",
month = "6",
day = "26",
language = "English (US)",
volume = "34",
pages = "259--265",
journal = "Kaku igaku. The Japanese journal of nuclear medicine",
issn = "0022-7854",
publisher = "Japanese Society of Nuclear Medicine",
number = "4",

}

TY - JOUR

T1 - Application of measuring 99mTc-MAG3 plasma clearance based on one- compartment model (MPC method) to pediatric patients

AU - Koizumi, Kiyoshi

AU - Higashida, K.

AU - Arbab, Ali Syed

AU - Toyama, K.

AU - Arai, T.

AU - Yoshitomi, T.

PY - 1997/6/26

Y1 - 1997/6/26

N2 - Measurement of 99mTc-MAG3 plasma clearance based on 1-compartment model (MPC method) were applied to 12 pediatric patients and evaluated for the factors which might affect the calculated results. Depth correction is a critical factor for the measurement of renal uptake. Three different equations for estimating renal depth were compared with the real depth measured by ultrasonography. The equation proposed by K. Itoh was suitable though the equations by T. Ito and Raynaud were insufficient. Estimation of distribution volume, which is regarded as circulating plasma volume (CPV), is also critical for the calculation of MAG3 clearance by MPC method. Precisely, hematocrit measured by venous sampling and circulating blood volume (CBV) calculated as 7.5% of body weight are used for estimation of CPV. However, assumed CPV as 5% of body weight was acceptable if the hematocrit was not severely deviated from the normal value. Simplified MPC method utilizing two factors mentioned above gave a positive correlation with Russell's one point sampling method. In conclusion, MPC method is applicable for pediatric patients.

AB - Measurement of 99mTc-MAG3 plasma clearance based on 1-compartment model (MPC method) were applied to 12 pediatric patients and evaluated for the factors which might affect the calculated results. Depth correction is a critical factor for the measurement of renal uptake. Three different equations for estimating renal depth were compared with the real depth measured by ultrasonography. The equation proposed by K. Itoh was suitable though the equations by T. Ito and Raynaud were insufficient. Estimation of distribution volume, which is regarded as circulating plasma volume (CPV), is also critical for the calculation of MAG3 clearance by MPC method. Precisely, hematocrit measured by venous sampling and circulating blood volume (CBV) calculated as 7.5% of body weight are used for estimation of CPV. However, assumed CPV as 5% of body weight was acceptable if the hematocrit was not severely deviated from the normal value. Simplified MPC method utilizing two factors mentioned above gave a positive correlation with Russell's one point sampling method. In conclusion, MPC method is applicable for pediatric patients.

KW - Plasma clearance

KW - Radionuclide renal study

KW - Renal function

KW - Tc-MAG3

UR - http://www.scopus.com/inward/record.url?scp=0030609917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030609917&partnerID=8YFLogxK

M3 - Article

VL - 34

SP - 259

EP - 265

JO - Kaku igaku. The Japanese journal of nuclear medicine

JF - Kaku igaku. The Japanese journal of nuclear medicine

SN - 0022-7854

IS - 4

ER -