Application of radiopaque micro-particle fillers for 3-D imaging of periodontal pocket analogues using cone beam CT

M. Elashiry, M. M. Meghil, Sajitha Menon Kalathingal, Allison K Buchanan, R. Elrefai, Stephen Warwick Looney, M. Rajendran, M. Ochieng, Nancy Beth Morgan Young, A. Elawady, Roger Mauricio Arce Munoz, K. H. Sandhage, Christopher W Cutler

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Periodontitis is an infectious/inflammatory disease most often diagnosed by deepening of the gingival sulcus, which leads to periodontal pockets (PPs) conventional manual periodontal probing does not provide detailed information on the three-dimensional (3-D) nature of PPs. Objectives: To determine whether accurate 3-D analyses of the depths and volumes of calibrated PP analogues (PPAs) can be obtained by conventional cone beam computed tomography (CBCT) coupled with novel radiopaque micro-particle fillers (described in the companion paper) injected into the PPAs. Methods: Two PPA models were employed: (1) a human skull model with artificial gingiva applied to teeth with alveolar bone loss and calibrated PPAs, and (2) a pig jaw model with alveolar bone loss and surgically-induced PPAs The PPAs were filled with controlled amounts of radiopaque micro-particle filler using volumetric pipetting Inter-method and intra-method agreement tests were then used to compare the PPA depths and volumes obtained from CBCT images with values obtained by masked examiners using calibrated manual methods. Results: Significant inter-method agreement (0.938–0.991) and intra-method agreement (0.94–0.99) were obtained when comparing analog manual data to digital CBCT measurements enabled by the radiopaque filler. Significance: CBCT imaging with radiopaque micro-particle fillers is a plausible means of visualizing and digitally assessing the depths, volumes, and 3-D shapes of PPs This approach could transform the diagnosis and treatment planning of periodontal disease, with particular initial utility in complex cases Efforts to confirm the clinical practicality of these fillers are currently in progress.

Original languageEnglish (US)
Pages (from-to)619-628
Number of pages10
JournalDental Materials
Volume34
Issue number4
DOIs
StatePublished - Apr 1 2018

Fingerprint

Periodontal Pocket
Cone-Beam Computed Tomography
Three-Dimensional Imaging
Fillers
Cones
Tomography
Imaging techniques
Alveolar Bone Loss
Bone
Periodontitis
Gingiva
Periodontal Diseases
Jaw
Skull
Communicable Diseases
Tooth
Swine
Planning

ASJC Scopus subject areas

  • Materials Science(all)
  • Dentistry(all)
  • Mechanics of Materials

Cite this

Application of radiopaque micro-particle fillers for 3-D imaging of periodontal pocket analogues using cone beam CT. / Elashiry, M.; Meghil, M. M.; Kalathingal, Sajitha Menon; Buchanan, Allison K; Elrefai, R.; Looney, Stephen Warwick; Rajendran, M.; Ochieng, M.; Young, Nancy Beth Morgan; Elawady, A.; Arce Munoz, Roger Mauricio; Sandhage, K. H.; Cutler, Christopher W.

In: Dental Materials, Vol. 34, No. 4, 01.04.2018, p. 619-628.

Research output: Contribution to journalArticle

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abstract = "Background: Periodontitis is an infectious/inflammatory disease most often diagnosed by deepening of the gingival sulcus, which leads to periodontal pockets (PPs) conventional manual periodontal probing does not provide detailed information on the three-dimensional (3-D) nature of PPs. Objectives: To determine whether accurate 3-D analyses of the depths and volumes of calibrated PP analogues (PPAs) can be obtained by conventional cone beam computed tomography (CBCT) coupled with novel radiopaque micro-particle fillers (described in the companion paper) injected into the PPAs. Methods: Two PPA models were employed: (1) a human skull model with artificial gingiva applied to teeth with alveolar bone loss and calibrated PPAs, and (2) a pig jaw model with alveolar bone loss and surgically-induced PPAs The PPAs were filled with controlled amounts of radiopaque micro-particle filler using volumetric pipetting Inter-method and intra-method agreement tests were then used to compare the PPA depths and volumes obtained from CBCT images with values obtained by masked examiners using calibrated manual methods. Results: Significant inter-method agreement (0.938–0.991) and intra-method agreement (0.94–0.99) were obtained when comparing analog manual data to digital CBCT measurements enabled by the radiopaque filler. Significance: CBCT imaging with radiopaque micro-particle fillers is a plausible means of visualizing and digitally assessing the depths, volumes, and 3-D shapes of PPs This approach could transform the diagnosis and treatment planning of periodontal disease, with particular initial utility in complex cases Efforts to confirm the clinical practicality of these fillers are currently in progress.",
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T1 - Application of radiopaque micro-particle fillers for 3-D imaging of periodontal pocket analogues using cone beam CT

AU - Elashiry, M.

AU - Meghil, M. M.

AU - Kalathingal, Sajitha Menon

AU - Buchanan, Allison K

AU - Elrefai, R.

AU - Looney, Stephen Warwick

AU - Rajendran, M.

AU - Ochieng, M.

AU - Young, Nancy Beth Morgan

AU - Elawady, A.

AU - Arce Munoz, Roger Mauricio

AU - Sandhage, K. H.

AU - Cutler, Christopher W

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N2 - Background: Periodontitis is an infectious/inflammatory disease most often diagnosed by deepening of the gingival sulcus, which leads to periodontal pockets (PPs) conventional manual periodontal probing does not provide detailed information on the three-dimensional (3-D) nature of PPs. Objectives: To determine whether accurate 3-D analyses of the depths and volumes of calibrated PP analogues (PPAs) can be obtained by conventional cone beam computed tomography (CBCT) coupled with novel radiopaque micro-particle fillers (described in the companion paper) injected into the PPAs. Methods: Two PPA models were employed: (1) a human skull model with artificial gingiva applied to teeth with alveolar bone loss and calibrated PPAs, and (2) a pig jaw model with alveolar bone loss and surgically-induced PPAs The PPAs were filled with controlled amounts of radiopaque micro-particle filler using volumetric pipetting Inter-method and intra-method agreement tests were then used to compare the PPA depths and volumes obtained from CBCT images with values obtained by masked examiners using calibrated manual methods. Results: Significant inter-method agreement (0.938–0.991) and intra-method agreement (0.94–0.99) were obtained when comparing analog manual data to digital CBCT measurements enabled by the radiopaque filler. Significance: CBCT imaging with radiopaque micro-particle fillers is a plausible means of visualizing and digitally assessing the depths, volumes, and 3-D shapes of PPs This approach could transform the diagnosis and treatment planning of periodontal disease, with particular initial utility in complex cases Efforts to confirm the clinical practicality of these fillers are currently in progress.

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