Application of unnatural amino acids to the de novo design of selective antibiotic peptides

Rickey Paige Hicks, Amanda L. Russell

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations

Abstract

Because of their unique mechanism of cytotoxicity against bacteria and other microorganisms, antimicrobial peptides have received a great deal of attention as possible therapeutic agents. Incorporation of unnatural amino acids into the peptide sequences has the potential to improve the organism selectivity and potency of these peptides as well as increase their metabolic stability. This protocol outlines the logic used to selectively incorporate unnatural amino acid into a peptide sequence in an attempt to obtain peptides with increased therapeutic potential as antibiotic agents.

Original languageEnglish (US)
Title of host publicationUnnatural Amino Acids
Subtitle of host publicationMethods and Protocols
EditorsLoredano Pollegioni, Stefano Servi
Pages135-167
Number of pages33
DOIs
StatePublished - Jan 1 2012

Publication series

NameMethods in Molecular Biology
Volume794
ISSN (Print)1064-3745

Keywords

  • Antimicrobial peptides
  • De novo
  • Organism selectivity
  • Unnatural amino acids

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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