Applications of Chemical Ligation in Peptide Synthesis via Acyl Transfer

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Abstract

The utility of native chemical ligation (NCL) in the solution or solid phase synthesis of peptides, cyclic peptides, glycopeptides, and neoglycoconjugates is reviewed. In addition, the mechanistic details of inter- or intra-molecular NCLs are discussed from experimental and computational points of view.

Original languageEnglish (US)
Pages (from-to)229-65
Number of pages37
JournalTopics in Current Chemistry
Volume362
DOIs
StatePublished - 2015

Keywords

  • Acylation
  • Molecular Structure
  • Peptides
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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