Abstract
The utility of native chemical ligation (NCL) in the solution or solid phase synthesis of peptides, cyclic peptides, glycopeptides, and neoglycoconjugates is reviewed. In addition, the mechanistic details of inter- or intra-molecular NCLs are discussed from experimental and computational points of view.
Original language | English (US) |
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Pages (from-to) | 229-65 |
Number of pages | 37 |
Journal | Topics in Current Chemistry |
Volume | 362 |
DOIs | |
State | Published - 2015 |
Keywords
- Acylation
- Molecular Structure
- Peptides
- Journal Article
- Research Support, Non-U.S. Gov't
- Review