Appropriate animal models for clinical studies

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Results from experiments with animal models can provide useful information relevant to human diet studies. They may indicate approximate levels of supplementation required to see an effect on the end-point measure of interest. They also allow investigation of metabolic responses that require invasive tissue sampling inappropriate for human studies. Animal studies carry the advantages of cost-effectiveness, speed, and control of potential confounding variables. However, results from animal studies cannot be directly extrapolated to clinical trials due to the absence of potential nutrient interactions, environmental stimuli, and learned food preferences and aversions that are experienced by human subjects.

Original languageEnglish (US)
Pages (from-to)155-168
Number of pages14
JournalAnnals of the New York Academy of Sciences
Volume819
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Fingerprint

Animals
Animal Models
Food Preferences
Confounding Factors (Epidemiology)
Cost Control
Nutrition
Cost effectiveness
Nutrients
Cost-Benefit Analysis
Clinical Trials
Tissue
Sampling
Diet
Food
Clinical Studies
Animal Model
Experiments
Interaction
Human Subjects
Stimulus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Appropriate animal models for clinical studies. / Harris, Ruth Babette.

In: Annals of the New York Academy of Sciences, Vol. 819, 01.01.1997, p. 155-168.

Research output: Contribution to journalArticle

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