AQP1 and SLC4A10 as candidate genes for primary open-angle glaucoma

Wenjing Liu, Yutao Liu, Xue Jun Qin, Silke Schmidt, Michael A. Hauser, R. Rand Allingham

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Purpose: Recent evidence supports the role of reduced cerebrospinal fluid (CSF) pressure in the pathogenesis of primary open-angle glaucoma (POAG). We investigated the association of variants in two candidate genes that are important in CSF production, aquaporin 1 (AQP1) and solute carrier family 4, sodium bicarbonate transporter, member 10 (SLC4A10), with POAG in the Caucasian population. Methods: POAG subjects (n=382) met the criteria of glaucomatous optic neuropathy with consistent visual field loss. Intraocular pressure was not used as an inclusion criterion. Control subjects (n=363) did not meet any of the inclusion criteria and had no family history of glaucoma. Eleven tagging single nucleotide polymorphisms (SNPs) for AQP1 and SLC4A10 were genotyped in the POAG and control subjects, using allelic discrimination assays. Genotype frequencies were compared between the POAG and control subjects, using logistic regression adjusted for gender. Results: There was no statistically significant difference in genotype frequencies between POAG and control subjects for any of the tested SNPs in AQP1 and SLC4A10 (p>0.05). Conclusions: There was no association between common sequence variants in the AQP1 or SLC4A10 genes and POAG in the Caucasian population. This is the first study to investigate the association between these two candidate genes and increased risk for POAG.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalMolecular Vision
Volume16
StatePublished - Aug 20 2010
Externally publishedYes

Fingerprint

Aquaporin 1
Genes
Single Nucleotide Polymorphism
Genotype
Cerebrospinal Fluid Pressure
Optic Nerve Diseases
Sodium Bicarbonate
Primary Open Angle Glaucoma
Visual Fields
Intraocular Pressure
Glaucoma
Population
Cerebrospinal Fluid
Logistic Models

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Liu, W., Liu, Y., Qin, X. J., Schmidt, S., Hauser, M. A., & Allingham, R. R. (2010). AQP1 and SLC4A10 as candidate genes for primary open-angle glaucoma. Molecular Vision, 16, 93-97.

AQP1 and SLC4A10 as candidate genes for primary open-angle glaucoma. / Liu, Wenjing; Liu, Yutao; Qin, Xue Jun; Schmidt, Silke; Hauser, Michael A.; Allingham, R. Rand.

In: Molecular Vision, Vol. 16, 20.08.2010, p. 93-97.

Research output: Contribution to journalArticle

Liu, W, Liu, Y, Qin, XJ, Schmidt, S, Hauser, MA & Allingham, RR 2010, 'AQP1 and SLC4A10 as candidate genes for primary open-angle glaucoma', Molecular Vision, vol. 16, pp. 93-97.
Liu W, Liu Y, Qin XJ, Schmidt S, Hauser MA, Allingham RR. AQP1 and SLC4A10 as candidate genes for primary open-angle glaucoma. Molecular Vision. 2010 Aug 20;16:93-97.
Liu, Wenjing ; Liu, Yutao ; Qin, Xue Jun ; Schmidt, Silke ; Hauser, Michael A. ; Allingham, R. Rand. / AQP1 and SLC4A10 as candidate genes for primary open-angle glaucoma. In: Molecular Vision. 2010 ; Vol. 16. pp. 93-97.
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