Aquaporins in the skin

Ravi Patel, L. Kevin Heard, Xunsheng Chen, Wendy B. Bollag

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

The skin is the largest organ of the body, serving as an important barrier between the internal milieu and the external environment. The skin is also one of the first lines of defense against microbial infection and other hazards, and thus, the skin has important immune functions. This organ is composed of many cell types, including immune-active dendritic cells (epidermal Langerhans cells and dermal dendritic cells), connective tissue-generating dermal fibroblasts and pigment-producing melanocytes. Comprising the outer skin layer are the epidermal keratinocytes, the predominant cell of this layer, the epidermis, which provides both a mechanical barrier and a water-permeability barrier. Recent data suggest that aquaporins, a family of barrel-shaped proteins surrounding internal pores that allow the passage of water and, in some family members, small solutes such as glycerol, play critical roles in regulating various skin parameters. The involvement of different aquaporin family members in skin function is discussed.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages173-191
Number of pages19
DOIs
StatePublished - Jan 1 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume969
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Aquaporin
  • Contact hypersensitivity
  • Epidermis
  • Glycerol
  • Psoriasis
  • Skin
  • Skin cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Patel, R., Kevin Heard, L., Chen, X., & Bollag, W. B. (2017). Aquaporins in the skin. In Advances in Experimental Medicine and Biology (pp. 173-191). (Advances in Experimental Medicine and Biology; Vol. 969). Springer New York LLC. https://doi.org/10.1007/978-94-024-1057-0_11