Arachidonic acid facilitates experimental chronic osteomyelitis in rats

J. P. Rissing, T. B. Buxton, J. Fisher, R. Harris, R. K. Shockley

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Arachidonic acid was used as a facilitating agent in experimental rat Staphylococcus aureus osteomyelitis and compared with the more commonly used agent, sodium morrhuate. The injection of arachidonic acid or sodium morrhuate and S. aureus into rat tibiae caused increased quantitative bacterial bone counts, gross bone pathology, roentgenographic changes, and weight loss. The doses required to produce these changes appeared to be lower for arachidonic acid.

Original languageEnglish (US)
Pages (from-to)141-144
Number of pages4
JournalInfection and Immunity
Issue number1
StatePublished - 1985

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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