Arginase: A multifaceted enzyme important in health and disease

Robert William Caldwell, Paulo C. Rodriguez, Haroldo Alfredo Flores Toque, Subhadra Priyadarshini Narayanan, Ruth B Caldwell

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

The arginase enzyme developed in early life forms and was maintained during evolution. As the last step in the urea cycle, arginase cleaves L-arginine to form urea and L-ornithine. The urea cycle provides protection against excess ammonia, while L-ornithine is needed for cell proliferation, collagen formation, and other physiological functions. In mammals, increases in arginase activity have been linked to dysfunction and pathologies of the cardiovascular system, kidney, and central nervous system and also to dysfunction of the immune system and cancer. Two important aspects of the excessive activity of arginase may be involved in diseases. First, overly active arginase can reduce the supply of L-arginine needed for the production of nitric oxide (NO) by NO synthase. Second, too much L-ornithine can lead to structural problems in the vasculature, neuronal toxicity, and abnormal growth of tumor cells. Seminal studies have demonstrated that increased formation of reactive oxygen species and key inflammatory mediators promote this pathological elevation of arginase activity. Here, we review the involvement of arginase in diseases affecting the cardiovascular, renal, and central nervous system and cancer and discuss the value of therapies targeting the elevated activity of arginase.

Original languageEnglish (US)
Pages (from-to)641-665
Number of pages25
JournalPhysiological reviews
Volume98
Issue number2
DOIs
StatePublished - Apr 1 2018

Fingerprint

Arginase
Health
Enzymes
Ornithine
Urea
Arginine
Central Nervous System
Kidney
L Forms
Neoplasms
Cardiovascular System
Ammonia
Nitric Oxide Synthase
Mammals
Immune System
Reactive Oxygen Species
Nitric Oxide
Cardiovascular Diseases
Collagen
Cell Proliferation

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Physiology (medical)

Cite this

Arginase : A multifaceted enzyme important in health and disease. / Caldwell, Robert William; Rodriguez, Paulo C.; Flores Toque, Haroldo Alfredo; Narayanan, Subhadra Priyadarshini; Caldwell, Ruth B.

In: Physiological reviews, Vol. 98, No. 2, 01.04.2018, p. 641-665.

Research output: Contribution to journalReview article

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