Arginase: An old enzyme with new tricks

Research output: Contribution to journalReview article

89 Citations (Scopus)

Abstract

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former provides protection against NH3; the latter serves to stimulate cell growth and other physiological functions. Excessive arginase activity in mammals has been associated with cardiovascular and nervous system dysfunction and disease. Two relevant aspects of this elevated activity may be involved in these disease states. First, excessive arginase activity reduces the supply of L-arginine needed by nitric oxide (NO) synthase to produce NO. Second, excessive production of ornithine leads to vascular structural problems and neural toxicity. Recent research has identified inflammatory agents and reactive oxygen species (ROS) as drivers of this pathologic elevation of arginase activity and expression. We review the involvement of arginase in cardiovascular and nervous system dysfunction, and discuss potential therapeutic interventions targeting excess arginase.

Original languageEnglish (US)
Pages (from-to)395-405
Number of pages11
JournalTrends in Pharmacological Sciences
Volume36
Issue number6
DOIs
StatePublished - Jan 1 2015

Fingerprint

Arginase
Enzymes
Cardiovascular system
Ornithine
Neurology
Cardiovascular System
Arginine
Mammals
Cell growth
Nervous System Diseases
Nitric Oxide Synthase
Nervous System
Blood Vessels
Toxicity
Urea
Reactive Oxygen Species
Nitric Oxide
Growth
Research

Keywords

  • Arginase
  • Neurodegeneration
  • Nitric oxide
  • Oxidative stress
  • Peroxynitrite
  • Polyamine
  • Superoxide
  • Vascular dysfunction

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Arginase : An old enzyme with new tricks. / Caldwell, Ruth B; Flores Toque, Haroldo Alfredo; Narayanan, Subhadra Priyadarshini; Caldwell, Robert William.

In: Trends in Pharmacological Sciences, Vol. 36, No. 6, 01.01.2015, p. 395-405.

Research output: Contribution to journalReview article

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AU - Caldwell, Robert William

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