Abstract
The present results agree with earlier reports that arginine stimulates in vivo release of insulin and glucagon in rats. Recently reported that ammonia provoked isolated rat islets to initially release a spike of glucagon but following this the arginine-induced release of glucagon was inhibited. In the present in vivo study, however, increased circulating ammonia did not change the basal concentration of plasma glucagon (not shown) nor the ability of arginine to stimulate glucagon release. We cannot explain the apparent lack of agreement in the results of these two studies with present evidence.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 527-528 |
| Number of pages | 2 |
| Journal | Hormone and Metabolic Research |
| Volume | 11 |
| Issue number | 9 |
| DOIs | |
| State | Published - Jan 1 1979 |
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ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical
Cite this
Arginine induced secretion of insulin and glucagon in rats with experimental hyperammonemia. / Mulloy, A. L.; Visek, W. J.
In: Hormone and Metabolic Research, Vol. 11, No. 9, 01.01.1979, p. 527-528.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Arginine induced secretion of insulin and glucagon in rats with experimental hyperammonemia
AU - Mulloy, A. L.
AU - Visek, W. J.
PY - 1979/1/1
Y1 - 1979/1/1
N2 - The present results agree with earlier reports that arginine stimulates in vivo release of insulin and glucagon in rats. Recently reported that ammonia provoked isolated rat islets to initially release a spike of glucagon but following this the arginine-induced release of glucagon was inhibited. In the present in vivo study, however, increased circulating ammonia did not change the basal concentration of plasma glucagon (not shown) nor the ability of arginine to stimulate glucagon release. We cannot explain the apparent lack of agreement in the results of these two studies with present evidence.
AB - The present results agree with earlier reports that arginine stimulates in vivo release of insulin and glucagon in rats. Recently reported that ammonia provoked isolated rat islets to initially release a spike of glucagon but following this the arginine-induced release of glucagon was inhibited. In the present in vivo study, however, increased circulating ammonia did not change the basal concentration of plasma glucagon (not shown) nor the ability of arginine to stimulate glucagon release. We cannot explain the apparent lack of agreement in the results of these two studies with present evidence.
UR - http://www.scopus.com/inward/record.url?scp=0018734726&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018734726&partnerID=8YFLogxK
U2 - 10.1055/s-0028-1095795
DO - 10.1055/s-0028-1095795
M3 - Article
C2 - 387566
AN - SCOPUS:0018734726
VL - 11
SP - 527
EP - 528
JO - Hormone and Metabolic Research
JF - Hormone and Metabolic Research
SN - 0018-5043
IS - 9
ER -