Arginine requirement of mature protein-malnourished rats for maximal rate of repletion

F. W. Kari, E. A. Ulman, A. L. Mulloy, W. J. Visek

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Male Sprague-Dawley rats (initial weight 400 g) were fed a 0.5% lactalbumin diet containing required amounts of all other known essential nutrients for 14 weeks. The body weights averaged 250 g after depletion when the animals were randomly assigned to four groups of four or five. Rats of one group were killed for baseline analyses on day 0 of repletion. The remaining three groups were repleted for 14 days with a complete L-amino acid diet containing 20% protein equivalent and 0, 0.75 or 1.5% Arg . HCl. Daily feed intakes averaged 11, 15 and 17 g and daily weight gains were 3.3, 7.4 and 8.3 g, respectively. Average values for corresponding groups were: nitrogen balance - 116, 187 and 190 mg/day; urinary orotate - 4.6, 0.8 and 0.15 mg/day; carcass lipid - 27, 37 and 40 g/100 g dry matter. Liver weights per 100 g body weight for 0 arginine exceeded other groups by 40%. There were no differences in creatinine index, nor in plasma concentrations of insulin, glucagon and albumin. The maximal rate of recovery from protein-calorie malnutrition of mature rats required an exogenous source of arginine. Urinary orotic acid excretion provided a reliable measure for determining when arginine needs for maximal rate of repletion were not met.

Original languageEnglish (US)
Pages (from-to)1489-1493
Number of pages5
JournalJournal of Nutrition
Volume111
Issue number8
StatePublished - Dec 1 1981

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Arginine
Body Weight
Orotic Acid
Diet
Weights and Measures
Lactalbumin
Protein-Energy Malnutrition
Proteins
Glucagon
Weight Gain
Sprague Dawley Rats
Albumins
Creatinine
Nitrogen
Insulin
Lipids
Amino Acids
Food
Liver

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Arginine requirement of mature protein-malnourished rats for maximal rate of repletion. / Kari, F. W.; Ulman, E. A.; Mulloy, A. L.; Visek, W. J.

In: Journal of Nutrition, Vol. 111, No. 8, 01.12.1981, p. 1489-1493.

Research output: Contribution to journalArticle

Kari, F. W. ; Ulman, E. A. ; Mulloy, A. L. ; Visek, W. J. / Arginine requirement of mature protein-malnourished rats for maximal rate of repletion. In: Journal of Nutrition. 1981 ; Vol. 111, No. 8. pp. 1489-1493.
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