Aripiprazole for agitation in a 13-year-old girl with neuroleptic malignant syndrome

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9 Citations (Scopus)

Abstract

Neuroleptic Malignant Syndrome (NMS) rarely results from atypical antipsychotic therapy. To date, no information is available on the incidence of NMS with aripiprazole, a newer neuroleptic. Objective: To examine the results of a trial of aripiprazole administered to a 13-year-old Mexican-American girl during the course of NMS. Methods: Vital signs and laboratory values obtained before and during the aripiprazole trial were compared. Results: Aripiprazole administration resulted in a mild increase in tachycardia and brief worsening of serum creatinine kinase level, but did not significantly affect temperature, respiratory rate, or blood pressure. Conclusions: In this adolescent with NMS, aripiprazole treatment was associated with a mild worsening of symptoms.

Original languageEnglish (US)
Pages (from-to)187-188
Number of pages2
JournalInternational Journal of Adolescent Medicine and Health
Volume17
Issue number2
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Fingerprint

Neuroleptic Malignant Syndrome
Antipsychotic Agents
Vital Signs
Respiratory Rate
Tachycardia
Creatinine
Phosphotransferases
Aripiprazole
Blood Pressure
Temperature
Incidence
Therapeutics
Serum

Keywords

  • Aripiprazole
  • Atypical antipsychotics
  • Neuroleptic Malignant Syndrome
  • United States

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Public Health, Environmental and Occupational Health

Cite this

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abstract = "Neuroleptic Malignant Syndrome (NMS) rarely results from atypical antipsychotic therapy. To date, no information is available on the incidence of NMS with aripiprazole, a newer neuroleptic. Objective: To examine the results of a trial of aripiprazole administered to a 13-year-old Mexican-American girl during the course of NMS. Methods: Vital signs and laboratory values obtained before and during the aripiprazole trial were compared. Results: Aripiprazole administration resulted in a mild increase in tachycardia and brief worsening of serum creatinine kinase level, but did not significantly affect temperature, respiratory rate, or blood pressure. Conclusions: In this adolescent with NMS, aripiprazole treatment was associated with a mild worsening of symptoms.",
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author = "Dew, {Rachel E.} and Rosenquist, {Peter B.} and McCall, {William Vaughn}",
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AU - Rosenquist, Peter B.

AU - McCall, William Vaughn

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N2 - Neuroleptic Malignant Syndrome (NMS) rarely results from atypical antipsychotic therapy. To date, no information is available on the incidence of NMS with aripiprazole, a newer neuroleptic. Objective: To examine the results of a trial of aripiprazole administered to a 13-year-old Mexican-American girl during the course of NMS. Methods: Vital signs and laboratory values obtained before and during the aripiprazole trial were compared. Results: Aripiprazole administration resulted in a mild increase in tachycardia and brief worsening of serum creatinine kinase level, but did not significantly affect temperature, respiratory rate, or blood pressure. Conclusions: In this adolescent with NMS, aripiprazole treatment was associated with a mild worsening of symptoms.

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