Aryl Hydrocarbon Receptor: A New Player of Pathogenesis and Therapy in Cardiovascular Diseases

Tao Yi, Jinxia Wang, Kaixi Zhu, Yao Liang Tang, Shian Huang, Xiaorong Shui, Yuanlin Ding, Can Chen, Wei Lei

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

The aryl hydrocarbon receptor (AhR) is a DNA binding protein that acts as a nuclear receptor mediating xenobiotic metabolism and environmental responses. Owing to the evolutionary conservation of this gene and its widespread expression in the immune and circulatory systems, AhR has for many years been almost exclusively studied by the pharmacological/toxicological field for its role in contaminant toxicity. More recently, the functions of AhR in environmental adaption have been examined in the context of the occurrence, development, and therapy of cardiovascular diseases. Increasing evidence suggests that AhR is involved in maintaining homeostasis or in triggering pathogenesis by modulating the biological responses of critical cell types in the cardiovascular system. Here, we describe the structure, distribution, and ligands of AhR and the AhR signaling pathway and review the impact of AhR on cardiovascular physiology. We also discuss the potential contribution of AhR as a new potential factor in the targeted treatment of cardiovascular diseases.

Original languageEnglish (US)
Article number6058784
JournalBioMed Research International
Volume2018
DOIs
StatePublished - Jan 1 2018

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Aryl Hydrocarbon Receptors
Cardiovascular Diseases
Therapeutics
Cardiovascular System
Cardiovascular Physiological Phenomena
Cardiovascular system
Physiology
DNA-Binding Proteins
Xenobiotics
Cytoplasmic and Nuclear Receptors
Metabolism
Toxicology
Toxicity
Immune System
Conservation
Homeostasis
Genes
Pharmacology
Impurities
Ligands

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Aryl Hydrocarbon Receptor : A New Player of Pathogenesis and Therapy in Cardiovascular Diseases. / Yi, Tao; Wang, Jinxia; Zhu, Kaixi; Tang, Yao Liang; Huang, Shian; Shui, Xiaorong; Ding, Yuanlin; Chen, Can; Lei, Wei.

In: BioMed Research International, Vol. 2018, 6058784, 01.01.2018.

Research output: Contribution to journalReview article

Yi, Tao ; Wang, Jinxia ; Zhu, Kaixi ; Tang, Yao Liang ; Huang, Shian ; Shui, Xiaorong ; Ding, Yuanlin ; Chen, Can ; Lei, Wei. / Aryl Hydrocarbon Receptor : A New Player of Pathogenesis and Therapy in Cardiovascular Diseases. In: BioMed Research International. 2018 ; Vol. 2018.
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AU - Huang, Shian

AU - Shui, Xiaorong

AU - Ding, Yuanlin

AU - Chen, Can

AU - Lei, Wei

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