Aspergillus flavus: An emerging non-fumigatus Aspergillus species of significance

Suganthini Krishnan, Elias Kurian Manavathu, Pranatharthi H. Chandrasekar

Research output: Contribution to journalReview article

128 Scopus citations

Abstract

Invasive aspergillosis is rare in immunocompetent people but contributes to significant morbidity and mortality in immunosuppressed patients. The majority (approximately 80%) of invasive Aspergillus infections is caused by Aspergillus fumigatus. The second most frequent (approximately 15-20%) pathogenic species is Aspergillus flavus and to a lesser extent, Aspergillus niger and Aspergillus terreus. Aspergillus flavus has emerged as a predominant pathogen in patients with fungal sinusitis and fungal keratitis in several institutions worldwide. To date, there has not been any publication exclusively reviewing the topic of A. flavus in the literature. This article reviews the microbiology, toxigenicity and epidemiology of A. flavus as well as describes the clinical characteristics, diagnosis and management of infections caused by this organism.

Original languageEnglish (US)
Pages (from-to)206-222
Number of pages17
JournalMycoses
Volume52
Issue number3
DOIs
Publication statusPublished - May 1 2009

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Keywords

  • Aflatoxin
  • Antifungal resistance
  • Aspergillus
  • Immunocompromised
  • Keratitis
  • Pulmonary aspergillosis
  • Sinusitis
  • Triazoles

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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