Aspirin-induced increases in soluble IL-1 receptor type II concentrations in vitro and in vivo

Jane M. Daun, Richard W. Ball, Heather R. Burger, Joseph G. Cannon

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

This study examined the influence of low-dose aspirin on interleukin (IL)-1β, IL-1 receptor antagonist (IL-1ra), and soluble receptor type II (sIL-1RII) secretion in vivo and in vitro. Blood mononuclear cells were isolated from healthy young men who ingested 81 mg of aspirin on alternate days for 2 weeks and from unmedicated controls. Aspirin had minor effects on ex vivo secretion of IL-1β and no influence on IL-1ra. In contrast, unstimulated ex vivo secretion of sIL-1RII was over twice as high by cells from aspirin-treated subjects (1115 ± 123 vs. 460 ± 77 pg/mL, P = 0.02). Lipopolysaccharide-stimulated sIL-1RII secretion was influenced similarly. Plasma sIL-1RII concentrations were 23% higher in aspirin-treated subjects (10.2 ± 0.6 vs. 8.4 ± 0.3 ng/mL, P = 0.03). In addition, cells from unmedicated subjects cultured in vitro with aspirin (10 μg/mL) secreted significantly greater amounts of sIL-1RII. Thus, low-dose aspirin therapy may prevent inflammation by increasing soluble receptor secretion, thereby preventing IL-1 from binding target cells.

Original languageEnglish (US)
Pages (from-to)863-866
Number of pages4
JournalJournal of Leukocyte Biology
Volume65
Issue number6
DOIs
StatePublished - Jan 1 1999

Keywords

  • Endotoxin
  • Human mononuclear cells
  • IL-1β

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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