Abstract
This study examined the influence of low-dose aspirin on interleukin (IL)-1β, IL-1 receptor antagonist (IL-1ra), and soluble receptor type II (sIL-1RII) secretion in vivo and in vitro. Blood mononuclear cells were isolated from healthy young men who ingested 81 mg of aspirin on alternate days for 2 weeks and from unmedicated controls. Aspirin had minor effects on ex vivo secretion of IL-1β and no influence on IL-1ra. In contrast, unstimulated ex vivo secretion of sIL-1RII was over twice as high by cells from aspirin-treated subjects (1115 ± 123 vs. 460 ± 77 pg/mL, P = 0.02). Lipopolysaccharide-stimulated sIL-1RII secretion was influenced similarly. Plasma sIL-1RII concentrations were 23% higher in aspirin-treated subjects (10.2 ± 0.6 vs. 8.4 ± 0.3 ng/mL, P = 0.03). In addition, cells from unmedicated subjects cultured in vitro with aspirin (10 μg/mL) secreted significantly greater amounts of sIL-1RII. Thus, low-dose aspirin therapy may prevent inflammation by increasing soluble receptor secretion, thereby preventing IL-1 from binding target cells.
Original language | English (US) |
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Pages (from-to) | 863-866 |
Number of pages | 4 |
Journal | Journal of Leukocyte Biology |
Volume | 65 |
Issue number | 6 |
DOIs | |
State | Published - 1999 |
Externally published | Yes |
Keywords
- Endotoxin
- Human mononuclear cells
- IL-1β
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Cell Biology