TY - JOUR
T1 - Assessment of carboxymethylcellulose and 32% dextran 70 for prevention of adhesions in a rabbit uterine horn model
AU - Diamond, M. P.
AU - DeCherney, A. H.
AU - Linsky, C. B.
AU - Cunningham, T.
AU - Constantine, B.
PY - 1988/1/1
Y1 - 1988/1/1
N2 - The ability of solutions of carboxymethylcellulose (CMC) and 32% dextran 70 to reduce postoperative ashesion formation was examined using a rabbit uterine-horn scrape model. Utilization of 50 mL of 32% dextran 70 did not reduce adhesion formation compared with control rabbits. However, intraperitoneal instillation of CMC significantly reduced postoperative adhesion formation. An inverse correlation was established between either the concentration of CMC employed (1%, 2%, and 3%) or the volume of 2% CMC employed (20, 30, 40, and 50 mL) and the extent of adhesion formation. It is concluded that in this animal model CMC, but not 32% dextran 70, was able to retard postoperative adhesion formation.
AB - The ability of solutions of carboxymethylcellulose (CMC) and 32% dextran 70 to reduce postoperative ashesion formation was examined using a rabbit uterine-horn scrape model. Utilization of 50 mL of 32% dextran 70 did not reduce adhesion formation compared with control rabbits. However, intraperitoneal instillation of CMC significantly reduced postoperative adhesion formation. An inverse correlation was established between either the concentration of CMC employed (1%, 2%, and 3%) or the volume of 2% CMC employed (20, 30, 40, and 50 mL) and the extent of adhesion formation. It is concluded that in this animal model CMC, but not 32% dextran 70, was able to retard postoperative adhesion formation.
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M3 - Article
C2 - 2459078
AN - SCOPUS:0023749918
SN - 0020-725X
VL - 33
SP - 278
EP - 282
JO - International Journal of Fertility
JF - International Journal of Fertility
IS - 4
ER -