Assessment of cefazolin and cefuroxime tissue penetration by using a continuous intravenous infusion

J. E. Connors, J. T. DiPiro, R. G. Hayter, K. D. Hooker, J. A. Stanfield, T. R. Young

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11 Scopus citations

Abstract

A continuous intravenous infusion was used to assess the tissue penetration of cefazolin (14 subjects) and cefuroxime (15 subjects) in orthopedic surgery patients. Subjects were randomly assigned to receive a continuous intravenous infusion of cefazolin (mean, 178.6 mg/h) or cefuroxime (mean, 330.0 mg/h) at a rate estimated to achieve a target steady-state total concentration of 50 μg/ml in serum. The infusion was initiated 12 to 14 h before surgery, and blood and muscle tissue samples were collected intraoperatively at the times of incision was wound closure. Although there was a significant difference between the free concentrations of cefazolin (at incision, 9.3 μg/ml; at closure, 9.2 μg/ml) and cefuroxime in serum (at incision, 26.9 μg/ml; at closure, 31.8 μg/ml), there was no difference in the total concentrations in muscle at either surgical incision (cefazolin, 6.1 μg/g; cefuroxime, 5.6 μg/g) or wound closure (cefazolin, 7.7 μg/g; cefuroxime, 7.4 μg/g). There was a significant correlation between the pooled free serum and total muscle concentrations for cefazolin (P = 0.001); however, there was no correlation between these variables with the pooleed cefuroxime data (P = 0.403). These findings indicate that the free drug concentration in serum alone is not consistently predictive of the total concentration of cephalosporin in muscle.

Original languageEnglish (US)
Pages (from-to)1128-1131
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume34
Issue number6
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Connors, J. E., DiPiro, J. T., Hayter, R. G., Hooker, K. D., Stanfield, J. A., & Young, T. R. (1990). Assessment of cefazolin and cefuroxime tissue penetration by using a continuous intravenous infusion. Antimicrobial Agents and Chemotherapy, 34(6), 1128-1131. https://doi.org/10.1128/AAC.34.6.1128