Assessment of cognitive function following magnesium therapy in the traumatically injured brain

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Many studies have examined the preclinical efficacy of Mg2+ therapy in models of traumatic brain injury. However, more of these studies have examined sensorimotor and motor performance than cognitive performance following injury. The present paper reviews the use of Mg2+ therapy to facilitate cognitive recovery in several models of cortical injury in the rodent. The first study examined the ability of daily injections of MgCl 2 (1 or 2 mmol) to impair acquisition of a reference memory task in the Morris Water Maze. Additional studies examined the ability of MgCl 2 to improve cognitive function following bilateral anterior medial cortex ablations, bilateral frontal cortex contusions, and unilateral frontal contusions. The results from these studies indicate that MgCl2 therapy is biologically active and readily crosses the blood-brain barrier because daily injections of MgCl2 impaired learning of a reference memory task in intact rats. Mg2+ therapy for brain injury revealed that administration of post-injury MgCl2 effectively improved recovery of cognitive deficits following injury. These results suggest that Mg2+ therapy is effective in facilitating cognitive recovery of function following brain injury; however, there are task and dose-dependent aspects to this recovery.

Original languageEnglish (US)
Pages (from-to)229-236
Number of pages8
JournalMagnesium Research
Volume20
Issue number4
DOIs
StatePublished - Dec 1 2007
Externally publishedYes

Fingerprint

Magnesium
Cognition
Magnesium Chloride
Brain
Recovery
Aptitude
Contusions
Wounds and Injuries
Brain Injuries
Data storage equipment
Therapeutics
Ablation
Injections
Recovery of Function
Rats
Frontal Lobe
Blood-Brain Barrier
Rodentia
Water
Learning

Keywords

  • Brain damage
  • Magnesium, cognitive performance
  • MWM
  • Recovery of function

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Assessment of cognitive function following magnesium therapy in the traumatically injured brain. / Hoane, Michael R.

In: Magnesium Research, Vol. 20, No. 4, 01.12.2007, p. 229-236.

Research output: Contribution to journalReview article

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