Assessment of the in vitro kinetic activity of caspofungin against Candida glabrata

V. Nagappan, D. Boikov, Jose Antonio Vazquez

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Echinocandins have become the drug of choice in infections caused by Candida glabrata. The objective of this study was to evaluate the in vitro activity of caspofungin alone and in combination against C. glabrata. In vitro assays demonstrated that caspofungin alone showed excellent fungicidal activity against C. glabrata, including fluconazole-resistant strains. The combination of caspofungin and azole antifungals showed potential synergy against C. glabrata. Overall, caspofungin demonstrated excellent in vitro activity, alone and in combination, against strains of C. glabrata.

Original languageEnglish (US)
Pages (from-to)522-525
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume54
Issue number1
DOIs
StatePublished - Jan 1 2010

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caspofungin
Candida glabrata
Echinocandins
Azoles
Fluconazole
In Vitro Techniques
Infection

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Assessment of the in vitro kinetic activity of caspofungin against Candida glabrata. / Nagappan, V.; Boikov, D.; Vazquez, Jose Antonio.

In: Antimicrobial Agents and Chemotherapy, Vol. 54, No. 1, 01.01.2010, p. 522-525.

Research output: Contribution to journalArticle

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