Assessment of the splanchnic vascular capacity and capacitance using quantitative equilibrium blood-pool scintigraphy

Vincent Jb Robinson, O. A. Smiseth, N. W. Scott-Douglas, E. R. Smith, J. V. Tyberg, D. E. Manyari

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A series of human and animal experiments were carried out to assess the usefulness of equilibrium blood pool scintigraphy (EBPS) to study acute changes of the splanchnic vascular capacity and the splanchnic vascular pressure-volume (P-V) relationship. Corrected regional abdominal count rate changes, before and after various pharmacologic interventions, were used to assess regional splanchnic vascular volume changes. Animals were instrumented to manipulate and record splanchnic venous pressures. In patients, splanchnic vascular capacity increased by 5.2 ± 6.9% (p < 0.001) after 0.6 mg sublingual nitroglycerin while no significant change was noted after sugar pills (0.9 ± 5.2%, p > 0.3). In dogs, splanchnic vascular capacity decreased by a mean of 16% during infusion of angiotensin (p < 0.001) and increased by a mean of 32% during infusion of nitroprusside (p < 0.001). The splanchnic vascular P-V curve was shifted rightwards during nitroglycerin administration. Thus, using the radionuclide technique we detected the expected qualitative and quantitative shifts in splanchnic capacity and capacitance. We conclude that EBPS is a useful method to assess acute changes of 1) the splanchnic vascular P-V relationship, in invasive animal studies, and 2) the splanchnic vascular capacity in noninvasive human and animal studies.

Original languageEnglish (US)
Pages (from-to)154-159
Number of pages6
JournalJournal of Nuclear Medicine
Volume31
Issue number2
StatePublished - Jan 1 1990
Externally publishedYes

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Vascular Capacitance
Gated Blood-Pool Imaging
Viscera
Blood Vessels
Pressure
Venous Pressure
Angiotensins
Nitroglycerin
Nitroprusside
Radioisotopes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Robinson, V. J., Smiseth, O. A., Scott-Douglas, N. W., Smith, E. R., Tyberg, J. V., & Manyari, D. E. (1990). Assessment of the splanchnic vascular capacity and capacitance using quantitative equilibrium blood-pool scintigraphy. Journal of Nuclear Medicine, 31(2), 154-159.

Assessment of the splanchnic vascular capacity and capacitance using quantitative equilibrium blood-pool scintigraphy. / Robinson, Vincent Jb; Smiseth, O. A.; Scott-Douglas, N. W.; Smith, E. R.; Tyberg, J. V.; Manyari, D. E.

In: Journal of Nuclear Medicine, Vol. 31, No. 2, 01.01.1990, p. 154-159.

Research output: Contribution to journalArticle

Robinson, VJ, Smiseth, OA, Scott-Douglas, NW, Smith, ER, Tyberg, JV & Manyari, DE 1990, 'Assessment of the splanchnic vascular capacity and capacitance using quantitative equilibrium blood-pool scintigraphy', Journal of Nuclear Medicine, vol. 31, no. 2, pp. 154-159.
Robinson, Vincent Jb ; Smiseth, O. A. ; Scott-Douglas, N. W. ; Smith, E. R. ; Tyberg, J. V. ; Manyari, D. E. / Assessment of the splanchnic vascular capacity and capacitance using quantitative equilibrium blood-pool scintigraphy. In: Journal of Nuclear Medicine. 1990 ; Vol. 31, No. 2. pp. 154-159.
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