Assisted reproduction and risk of preterm birth in singletons by infertility diagnoses and treatment modalities: a population-based study

Galit Levi Dunietz, Claudia Holzman, Yujia Zhang, Chenxi Li, David Todem, Sheree L. Boulet, Patricia McKane, Dmitry M. Kissin, Glenn Copeland, Dana Bernson, Michael Peter Diamond

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: The purpose of this study is to examine the spectrum of infertility diagnoses and assisted reproductive technology (ART) treatments in relation to risk of preterm birth (PTB) in singletons. Methods: Population-based assisted reproductive technology surveillance data for 2000–2010 were linked with birth certificates from three states: Florida, Massachusetts, and Michigan, resulting in a sample of 4,370,361 non-ART and 28,430 ART-related singletons. Logistic regression models with robust variance estimators were used to compare PTB risk among singletons conceived with and without ART, the former grouped by parental infertility diagnoses and treatment modalities. Demographic and pregnancy factors were included in adjusted analyses. Results: ART was associated with increased PTB risk across all infertility diagnosis groups and treatment types: for conventional ART, adjusted relative risks ranged from 1.4 (95% CI 1.0, 1.9) for male infertility to 2.4 (95% CI 1.8, 3.3) for tubal ligation. Adding intra-cytoplasmic sperm injection and/or assisted hatching to conventional ART treatment did not alter associated PTB risks. Singletons conceived by mothers without infertility diagnosis and with donor semen had an increased PTB risk relative to non-ART singletons. Conclusions: PTB risk among ART singletons is increased within each treatment type and all underlying infertility diagnosis, including male infertility. Preterm birth in ART singletons may be attributed to parental infertility, ART treatments, or their combination.

Original languageEnglish (US)
Pages (from-to)1529-1535
Number of pages7
JournalJournal of Assisted Reproduction and Genetics
Volume34
Issue number11
DOIs
StatePublished - Nov 1 2017

Fingerprint

Assisted Reproductive Techniques
Premature Birth
Infertility
Reproduction
Population
Reproductive Techniques
Therapeutics
Male Infertility
Logistic Models
Birth Certificates
Tubal Sterilization
Spermatozoa
Mothers
Demography
Tissue Donors
Pregnancy

Keywords

  • Assisted hatching
  • Assisted reproductive technology
  • Donor oocytes or embryos
  • Infertility
  • Intra-cytoplasmic sperm injection
  • Preterm birth

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)

Cite this

Assisted reproduction and risk of preterm birth in singletons by infertility diagnoses and treatment modalities : a population-based study. / Dunietz, Galit Levi; Holzman, Claudia; Zhang, Yujia; Li, Chenxi; Todem, David; Boulet, Sheree L.; McKane, Patricia; Kissin, Dmitry M.; Copeland, Glenn; Bernson, Dana; Diamond, Michael Peter.

In: Journal of Assisted Reproduction and Genetics, Vol. 34, No. 11, 01.11.2017, p. 1529-1535.

Research output: Contribution to journalArticle

Dunietz, Galit Levi ; Holzman, Claudia ; Zhang, Yujia ; Li, Chenxi ; Todem, David ; Boulet, Sheree L. ; McKane, Patricia ; Kissin, Dmitry M. ; Copeland, Glenn ; Bernson, Dana ; Diamond, Michael Peter. / Assisted reproduction and risk of preterm birth in singletons by infertility diagnoses and treatment modalities : a population-based study. In: Journal of Assisted Reproduction and Genetics. 2017 ; Vol. 34, No. 11. pp. 1529-1535.
@article{1bde710f74774f75b192a47b44467c42,
title = "Assisted reproduction and risk of preterm birth in singletons by infertility diagnoses and treatment modalities: a population-based study",
abstract = "Purpose: The purpose of this study is to examine the spectrum of infertility diagnoses and assisted reproductive technology (ART) treatments in relation to risk of preterm birth (PTB) in singletons. Methods: Population-based assisted reproductive technology surveillance data for 2000–2010 were linked with birth certificates from three states: Florida, Massachusetts, and Michigan, resulting in a sample of 4,370,361 non-ART and 28,430 ART-related singletons. Logistic regression models with robust variance estimators were used to compare PTB risk among singletons conceived with and without ART, the former grouped by parental infertility diagnoses and treatment modalities. Demographic and pregnancy factors were included in adjusted analyses. Results: ART was associated with increased PTB risk across all infertility diagnosis groups and treatment types: for conventional ART, adjusted relative risks ranged from 1.4 (95{\%} CI 1.0, 1.9) for male infertility to 2.4 (95{\%} CI 1.8, 3.3) for tubal ligation. Adding intra-cytoplasmic sperm injection and/or assisted hatching to conventional ART treatment did not alter associated PTB risks. Singletons conceived by mothers without infertility diagnosis and with donor semen had an increased PTB risk relative to non-ART singletons. Conclusions: PTB risk among ART singletons is increased within each treatment type and all underlying infertility diagnosis, including male infertility. Preterm birth in ART singletons may be attributed to parental infertility, ART treatments, or their combination.",
keywords = "Assisted hatching, Assisted reproductive technology, Donor oocytes or embryos, Infertility, Intra-cytoplasmic sperm injection, Preterm birth",
author = "Dunietz, {Galit Levi} and Claudia Holzman and Yujia Zhang and Chenxi Li and David Todem and Boulet, {Sheree L.} and Patricia McKane and Kissin, {Dmitry M.} and Glenn Copeland and Dana Bernson and Diamond, {Michael Peter}",
year = "2017",
month = "11",
day = "1",
doi = "10.1007/s10815-017-1003-6",
language = "English (US)",
volume = "34",
pages = "1529--1535",
journal = "Journal of Assisted Reproduction and Genetics",
issn = "1058-0468",
publisher = "Springer New York",
number = "11",

}

TY - JOUR

T1 - Assisted reproduction and risk of preterm birth in singletons by infertility diagnoses and treatment modalities

T2 - a population-based study

AU - Dunietz, Galit Levi

AU - Holzman, Claudia

AU - Zhang, Yujia

AU - Li, Chenxi

AU - Todem, David

AU - Boulet, Sheree L.

AU - McKane, Patricia

AU - Kissin, Dmitry M.

AU - Copeland, Glenn

AU - Bernson, Dana

AU - Diamond, Michael Peter

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Purpose: The purpose of this study is to examine the spectrum of infertility diagnoses and assisted reproductive technology (ART) treatments in relation to risk of preterm birth (PTB) in singletons. Methods: Population-based assisted reproductive technology surveillance data for 2000–2010 were linked with birth certificates from three states: Florida, Massachusetts, and Michigan, resulting in a sample of 4,370,361 non-ART and 28,430 ART-related singletons. Logistic regression models with robust variance estimators were used to compare PTB risk among singletons conceived with and without ART, the former grouped by parental infertility diagnoses and treatment modalities. Demographic and pregnancy factors were included in adjusted analyses. Results: ART was associated with increased PTB risk across all infertility diagnosis groups and treatment types: for conventional ART, adjusted relative risks ranged from 1.4 (95% CI 1.0, 1.9) for male infertility to 2.4 (95% CI 1.8, 3.3) for tubal ligation. Adding intra-cytoplasmic sperm injection and/or assisted hatching to conventional ART treatment did not alter associated PTB risks. Singletons conceived by mothers without infertility diagnosis and with donor semen had an increased PTB risk relative to non-ART singletons. Conclusions: PTB risk among ART singletons is increased within each treatment type and all underlying infertility diagnosis, including male infertility. Preterm birth in ART singletons may be attributed to parental infertility, ART treatments, or their combination.

AB - Purpose: The purpose of this study is to examine the spectrum of infertility diagnoses and assisted reproductive technology (ART) treatments in relation to risk of preterm birth (PTB) in singletons. Methods: Population-based assisted reproductive technology surveillance data for 2000–2010 were linked with birth certificates from three states: Florida, Massachusetts, and Michigan, resulting in a sample of 4,370,361 non-ART and 28,430 ART-related singletons. Logistic regression models with robust variance estimators were used to compare PTB risk among singletons conceived with and without ART, the former grouped by parental infertility diagnoses and treatment modalities. Demographic and pregnancy factors were included in adjusted analyses. Results: ART was associated with increased PTB risk across all infertility diagnosis groups and treatment types: for conventional ART, adjusted relative risks ranged from 1.4 (95% CI 1.0, 1.9) for male infertility to 2.4 (95% CI 1.8, 3.3) for tubal ligation. Adding intra-cytoplasmic sperm injection and/or assisted hatching to conventional ART treatment did not alter associated PTB risks. Singletons conceived by mothers without infertility diagnosis and with donor semen had an increased PTB risk relative to non-ART singletons. Conclusions: PTB risk among ART singletons is increased within each treatment type and all underlying infertility diagnosis, including male infertility. Preterm birth in ART singletons may be attributed to parental infertility, ART treatments, or their combination.

KW - Assisted hatching

KW - Assisted reproductive technology

KW - Donor oocytes or embryos

KW - Infertility

KW - Intra-cytoplasmic sperm injection

KW - Preterm birth

UR - http://www.scopus.com/inward/record.url?scp=85026465928&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026465928&partnerID=8YFLogxK

U2 - 10.1007/s10815-017-1003-6

DO - 10.1007/s10815-017-1003-6

M3 - Article

C2 - 28755152

AN - SCOPUS:85026465928

VL - 34

SP - 1529

EP - 1535

JO - Journal of Assisted Reproduction and Genetics

JF - Journal of Assisted Reproduction and Genetics

SN - 1058-0468

IS - 11

ER -