Association analysis between polymorphisms of PON gene cluster with coronary heart disease in Chinese

Xiao Ling Wang, Zhong Jie Fan, Jian Feng Huang, Shao Yong Su, Jian Gong Zhao, Dong Feng Gu

Research output: Contribution to journalArticle

Abstract

An extensive association analysis of PON gene cluster (PONs) with coronary heart disease (CHD) was performed in Chinese Man population. Eleven polymorphisms of PON1, PON2 and PON3 gene were investigated for association with CHD in 474 male patients and 475 controls. Univariate analyses showed the cases had significantly higher frequencies of PON1 192Q allele, 160R allele, -162A allele and PON2 311C allele than were seen in the controls. Logistic regression analyses revealed only the PON1 R160G and -162G/A polymorphisms remained significantly associated with CHD (P = 0.0054 and P = 0.0002). Haplotype analyses for various polymorphism combinations further confirmed the results of individual polymorphism analyses. Only the frequencies of haplotypes containing -162A allele were significantly higher, whereas only the frequencies of haplotypes containing 160G allele significantly lower in cases than those in controls in various polymorphism combinations. This extensive association study has identified the PON1 -162G/A and R160G polymorphisms to be independently associated with CHD in Chinese Han population, and warrants further study to elucidate the biological mechanism.

Original languageEnglish (US)
Pages (from-to)675-681
Number of pages7
JournalActa Genetica Sinica
Volume32
Issue number7
StatePublished - Jul 1 2005
Externally publishedYes

Keywords

  • Coronary heart disease
  • Genetics
  • LDL oxidation
  • Linkage disequilibrium
  • Paraoxonase

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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