Association between angiotensin II type I receptor polymorphism and resting hemodynamics in Black and White youth

Paule Barbeau, Anita Kulharya, Gregory A Harshfield, Harold Snieder, Harry Davis, Frank Treiber

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives: An angiotensin II type I receptor polymorphism (AGTR1/A1166C) was previously found to be associated with hypertension. The purpose of this study was to investigate the relationship between this polymorphism and resting measures of hemodynamics in normotensive youth. Design: Subjects were 41 Whites (mean ± SD: 18 ± 3 y old, 26 males) and 73 Blacks (19 ± 2 y old, 55 males) with a positive family history of hypertension. Methods: Hemodynamic measures included resting systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR). Results: Allele frequencies were significantly different (x2 = 14.10, P≤.001) between Whites and Blacks (.23 vs. 06 for the C allele, respectively). For all subsequent analyses, subjects were categorized into two genotype groups, carriers and non-carriers of the C allele, because only two Whites and no Blacks were homozygous for the C allele. Genotype frequencies were significantly different (x2 = 12.66, P≤.001) between Whites and Blacks (.41 vs. 12 for the carriers, respectively). Among Whites, univariate analyses of covariance, using body mass index and age as covariates, indicated that carriers of the C allele compared to non-carriers, had a higher DBP (61.6 ± 6.7 VS 57.8 ± 6.2 mm Hg, P≤.05) and HR (68.0 ± 10.5 vs 61.1 ± 8.1, P≤.05). Genotype was not associated with resting hemodynamic measures in Blacks (all P values>.05). Conclusions: These results are consistent with findings that have typically involved White adults, and demonstrate that the renin system does not seem to play as great a role in BP control in Blacks as it does in Whites.

Original languageEnglish (US)
JournalEthnicity and Disease
Volume12
Issue number1
StatePublished - May 18 2002

Fingerprint

Angiotensin I
Angiotensin Receptors
Hemodynamics
Blood Pressure
Alleles
Genotype
Hypertension
Heart Rate
Renin
Gene Frequency
Body Mass Index
hydroquinone

Keywords

  • Blood pressure
  • Ethnicity
  • Gene
  • Hypertension
  • Renin system
  • Youth

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Medicine(all)

Cite this

Association between angiotensin II type I receptor polymorphism and resting hemodynamics in Black and White youth. / Barbeau, Paule; Kulharya, Anita; Harshfield, Gregory A; Snieder, Harold; Davis, Harry; Treiber, Frank.

In: Ethnicity and Disease, Vol. 12, No. 1, 18.05.2002.

Research output: Contribution to journalArticle

Barbeau, Paule ; Kulharya, Anita ; Harshfield, Gregory A ; Snieder, Harold ; Davis, Harry ; Treiber, Frank. / Association between angiotensin II type I receptor polymorphism and resting hemodynamics in Black and White youth. In: Ethnicity and Disease. 2002 ; Vol. 12, No. 1.
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