Association between angiotensin II type I receptor polymorphism and resting hemodynamics in Black and White youth

Paule Barbeau, Anita Kulharya, Gregory Harshfield, Harold Snieder, Harry Davis, Frank Treiber

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Objectives: An angiotensin II type I receptor polymorphism (AGTR1/A1166C) was previously found to be associated with hypertension. The purpose of this study was to investigate the relationship between this polymorphism and resting measures of hemodynamics in normotensive youth. Design: Subjects were 41 Whites (mean ± SD: 18 ± 3 y old, 26 males) and 73 Blacks (19 ± 2 y old, 55 males) with a positive family history of hypertension. Methods: Hemodynamic measures included resting systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR). Results: Allele frequencies were significantly different (x2 = 14.10, P≤.001) between Whites and Blacks (.23 vs. 06 for the C allele, respectively). For all subsequent analyses, subjects were categorized into two genotype groups, carriers and non-carriers of the C allele, because only two Whites and no Blacks were homozygous for the C allele. Genotype frequencies were significantly different (x2 = 12.66, P≤.001) between Whites and Blacks (.41 vs. 12 for the carriers, respectively). Among Whites, univariate analyses of covariance, using body mass index and age as covariates, indicated that carriers of the C allele compared to non-carriers, had a higher DBP (61.6 ± 6.7 VS 57.8 ± 6.2 mm Hg, P≤.05) and HR (68.0 ± 10.5 vs 61.1 ± 8.1, P≤.05). Genotype was not associated with resting hemodynamic measures in Blacks (all P values>.05). Conclusions: These results are consistent with findings that have typically involved White adults, and demonstrate that the renin system does not seem to play as great a role in BP control in Blacks as it does in Whites.

Original languageEnglish (US)
Pages (from-to)S1-68-S1-71
JournalEthnicity and Disease
Volume12
Issue number1
StatePublished - 2002

Keywords

  • Blood pressure
  • Ethnicity
  • Gene
  • Hypertension
  • Renin system
  • Youth

ASJC Scopus subject areas

  • Epidemiology

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    Barbeau, P., Kulharya, A., Harshfield, G., Snieder, H., Davis, H., & Treiber, F. (2002). Association between angiotensin II type I receptor polymorphism and resting hemodynamics in Black and White youth. Ethnicity and Disease, 12(1), S1-68-S1-71.