TY - JOUR
T1 - Association between gastro-oesophageal reflux disease and dental erosion in children
T2 - A systematic review and meta-analysis
AU - Li, Yuanyuan
AU - Wang, Zhibin
AU - Fang, Ming
AU - Tay, Franklin R.
AU - Chen, Xin
N1 - Funding Information:
We thank the authors who provided usable but unreported data of the studies included in the present work.
Publisher Copyright:
© 2022
PY - 2022/10
Y1 - 2022/10
N2 - Objectives: To perform systematic review and quantitative analysis of the literature on the association between gastro-oesophageal reflux disease (GERD) and dental erosion in children. Methods: Databases were searched for randomised controlled trials, cohort studies, cross-sectional surveys and case-control studies that evaluated the association between GERD and dental erosion in children aged 1–18 years, without limitations on the language or year of publication. Data were pooled in random effects models. Data sources included Embase, MEDLINE, Web of Science, Trip Pro, Cochrane Library, the International Clinical Trials Registry Platform, ClinicaTrials.gov, Open Grey, Proquest Dissertations and Thesis and Google Scholar from inception to June 9, 2022. Results: Thirteen studies were included, of which twelve were used for meta-analysis. There were strong associations between GERD and enamel erosion with the subject as unit (odds ratio 4.46; 95% confidence interval (CI) 1.93–10.30; n = 6774); dentine erosion with the subject as unit (odds ratio 13.39; 95% CI 4.17–42.94; n = 371); enamel erosion with the tooth as unit (odds ratio 3.29; 95% CI 1.36–7.95; n = 4637); as well as dentine erosion with the tooth as unit (odds ratio 5.91; 95% CI, 2.35–14.86; n = 4637). In cohort studies, GERD was associated with a higher risk of enamel erosion with the subject as a unit (relative risk 1.88, 95% CI 1.22–2.92; n = 1411). Conclusions: Gastro-oesophageal reflux disease is associated with dental erosion in children. The heterogeneity of GERD definition should be considered when interpreting the present work. Clinical significance: There is a positive association between GERD and dental erosion in children. Dentists should emphasise timely detection and management of the underlying factors of dental erosion in GERD. Future studies should define paediatric GERD according to a universal guideline to better enhance patient care.
AB - Objectives: To perform systematic review and quantitative analysis of the literature on the association between gastro-oesophageal reflux disease (GERD) and dental erosion in children. Methods: Databases were searched for randomised controlled trials, cohort studies, cross-sectional surveys and case-control studies that evaluated the association between GERD and dental erosion in children aged 1–18 years, without limitations on the language or year of publication. Data were pooled in random effects models. Data sources included Embase, MEDLINE, Web of Science, Trip Pro, Cochrane Library, the International Clinical Trials Registry Platform, ClinicaTrials.gov, Open Grey, Proquest Dissertations and Thesis and Google Scholar from inception to June 9, 2022. Results: Thirteen studies were included, of which twelve were used for meta-analysis. There were strong associations between GERD and enamel erosion with the subject as unit (odds ratio 4.46; 95% confidence interval (CI) 1.93–10.30; n = 6774); dentine erosion with the subject as unit (odds ratio 13.39; 95% CI 4.17–42.94; n = 371); enamel erosion with the tooth as unit (odds ratio 3.29; 95% CI 1.36–7.95; n = 4637); as well as dentine erosion with the tooth as unit (odds ratio 5.91; 95% CI, 2.35–14.86; n = 4637). In cohort studies, GERD was associated with a higher risk of enamel erosion with the subject as a unit (relative risk 1.88, 95% CI 1.22–2.92; n = 1411). Conclusions: Gastro-oesophageal reflux disease is associated with dental erosion in children. The heterogeneity of GERD definition should be considered when interpreting the present work. Clinical significance: There is a positive association between GERD and dental erosion in children. Dentists should emphasise timely detection and management of the underlying factors of dental erosion in GERD. Future studies should define paediatric GERD according to a universal guideline to better enhance patient care.
KW - Dental erosion
KW - Gastro-oesophageal reflux disease
KW - Meta-analysis
KW - Paediatric dentistry
KW - Preventive dentistry
KW - Systematic reviews
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U2 - 10.1016/j.jdent.2022.104247
DO - 10.1016/j.jdent.2022.104247
M3 - Review article
C2 - 35917996
AN - SCOPUS:85135927202
SN - 0300-5712
VL - 125
JO - Journal of Dentistry
JF - Journal of Dentistry
M1 - 104247
ER -