Association between marijuana use and transitional cell carcinoma

Julie A. Chacko, Jared G. Heiner, Wendy Siu, Marie Macy, Martha Kennedy Terris

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objectives. Marijuana smoking has been implicated as a causative factor in traditionally tobacco-related tumors of the head and neck and of the lung. When associated with marijuana use, such tumors occur in a much younger patient population than do similar tumors in tobacco smokers. Owing to the large number of young men with a history of marijuana presenting with transitional cell carcinoma to VA facilities, this study was designed to compare the marijuana use among young (aged less than 60 years) transitional cell carcinoma patients with that among age-matched controls. Methods. Fifty-two men aged less than 60 years presenting consecutively with transitional cell carcinoma and 104 age-matched controls (defined by having no history of transitional cell carcinoma, hematuria, or irritative voiding symptoms, as well as unremarkable results on urinalysis and urine cytology) completed questionnaires about exposure to various potential carcinogens, including radiation, Agent Orange, smoked or processed meats, dyes, tobacco, and marijuana. Results. Of the 52 transitional cell carcinoma patients, 46 (88.5%) reported a history of habitual marijuana usage, and 72 (69.2%) of the age-matched controls gave a history of habitual marijuana use. This difference was statistically significant (P = 0.008). In those with transitional cell carcinoma, marijuana use significantly correlated with tumor stage, grade, and number of recurrences. Conclusions. Marijuana smoking might increase the risk of transitional cell carcinoma.

Original languageEnglish (US)
Pages (from-to)100-104
Number of pages5
JournalUrology
Volume67
Issue number1
DOIs
StatePublished - Jan 1 2006

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Transitional Cell Carcinoma
Cannabis
Marijuana Smoking
Tobacco
Neoplasms
Urinalysis
Hematuria
Carcinogens
Meat
Cell Biology
Coloring Agents
Neck
Head
Urine
Radiation
Recurrence
Lung
Population

ASJC Scopus subject areas

  • Urology

Cite this

Association between marijuana use and transitional cell carcinoma. / Chacko, Julie A.; Heiner, Jared G.; Siu, Wendy; Macy, Marie; Terris, Martha Kennedy.

In: Urology, Vol. 67, No. 1, 01.01.2006, p. 100-104.

Research output: Contribution to journalArticle

Chacko, Julie A. ; Heiner, Jared G. ; Siu, Wendy ; Macy, Marie ; Terris, Martha Kennedy. / Association between marijuana use and transitional cell carcinoma. In: Urology. 2006 ; Vol. 67, No. 1. pp. 100-104.
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