Association between mutations of the follicle-stimulating-hormone receptor and repeated twinning

Ayman Al-Hendy, Oksana Moshynska, Anurag Saxena, Valter Feyles

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Follicle-stimulating hormone (FSH) has a role in folliculogenesis and spontaneous twinning. Using the candidate gene approach, we searched for mutations in the gene encoding the FSH receptor in a woman who had given birth to two sets of dizygotic twins without fertility treatment. We identified two linked mutations (Thr307Ala and Asn680Ser) that were closely associated with this phenotype. We suggest that expression of both mutations increases the sensitivity of the receptor to FSH.

Original languageEnglish (US)
Number of pages1
JournalLancet
Volume356
Issue number9233
DOIs
StatePublished - Sep 9 2000

ASJC Scopus subject areas

  • Medicine(all)

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