Association between polymorphic blood markers and risk factors for cardiovascular disease in a large pedigree

Varghese George, Robert C. Elston, Chris I. Amos, Laura J. Ward, Gerald S. Berenson, D. C. Rao

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A large pedigree with high prevalence of heart disease is investigated to analyse the association between polymorphic blood markers and quantitative risk factors for cardiovascular disease. The analysis incorporates a familial correlation structure among the individuals in the pedigree and a generalized power transformation to induce approximate residual normality of the risk factors. A total of 380 marker/ risk factor combinations are analysed, and at the nominal 1 % significance level, positive associations are found between the A antigen of the ABO locus and both serum total cholesterol and low-density lipoprotein cholesterol, and negative associations are found between the B antigen of the ABO locus and serum total cholesterol, and between the B allele of acid phosphatase (AP) locus and systolic blood pressure.

Original languageEnglish (US)
Pages (from-to)267-275
Number of pages9
JournalGenetic Epidemiology
Issue number4
StatePublished - Jan 1 1987



  • ABO blood group
  • low-density lipoprotein cholesterol
  • systolic blood pressure
  • total cholesterol

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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