Association between polymorphic blood markers and risk factors for cardiovascular disease in a large pedigree

Varghese George, Robert C. Elston, Chris I. Amos, Laura J. Ward, Gerald S. Berenson, D. C. Rao

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A large pedigree with high prevalence of heart disease is investigated to analyse the association between polymorphic blood markers and quantitative risk factors for cardiovascular disease. The analysis incorporates a familial correlation structure among the individuals in the pedigree and a generalized power transformation to induce approximate residual normality of the risk factors. A total of 380 marker/ risk factor combinations are analysed, and at the nominal 1 % significance level, positive associations are found between the A antigen of the ABO locus and both serum total cholesterol and low-density lipoprotein cholesterol, and negative associations are found between the B antigen of the ABO locus and serum total cholesterol, and between the B allele of acid phosphatase (AP) locus and systolic blood pressure.

Original languageEnglish (US)
Pages (from-to)267-275
Number of pages9
JournalGenetic Epidemiology
Volume4
Issue number4
DOIs
StatePublished - Jan 1 1987

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Pedigree
Cardiovascular Diseases
Cholesterol
Blood Pressure
Antigens
Serum
LDL Cholesterol
Heart Diseases
Alleles

Keywords

  • ABO blood group
  • low-density lipoprotein cholesterol
  • systolic blood pressure
  • total cholesterol

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

Cite this

Association between polymorphic blood markers and risk factors for cardiovascular disease in a large pedigree. / George, Varghese; Elston, Robert C.; Amos, Chris I.; Ward, Laura J.; Berenson, Gerald S.; Rao, D. C.

In: Genetic Epidemiology, Vol. 4, No. 4, 01.01.1987, p. 267-275.

Research output: Contribution to journalArticle

George, Varghese ; Elston, Robert C. ; Amos, Chris I. ; Ward, Laura J. ; Berenson, Gerald S. ; Rao, D. C. / Association between polymorphic blood markers and risk factors for cardiovascular disease in a large pedigree. In: Genetic Epidemiology. 1987 ; Vol. 4, No. 4. pp. 267-275.
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