Association between the Thr715Pro P-selectin gene polymorphism and soluble P-selectin levels in a multiethnic population in South London

Michelle A. Miller, Sally M. Kerry, Yanbin Dong, Pasquale Strazzullo, Francesco P. Cappuccio

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The aim was to investigate whether the Thr715Pro P-selectin polymorphism is associated with soluble P-selectin (sP-selectin) levels in individuals from different ethnic groups. Plasma sP-selectin and Thr715Pro (A/C) P-selectin gene polymorphism were measured in 237 white (106 females), 177 black African origin (92 females) and 201 South Asian (94 females) individuals living in England. All were free from coronary heart disease (CHD), stroke and other cardiovascular disease, diabetes, drug therapy for hypertension or high lipids, hormone replacement therapy or oral contraceptive pill. The Thr715Pro C allele was rare in blacks (0.8%) and intermediate in South Asians (3.0%) compared to whites (11.2%; p < 0.001). sP-selectin levels were significantly lower in the individuals with the AC or CC compared to the AA genotype in both whites (-25% (95% C.I. -33.3 to -16.9); p < 0.001) and South Asians (-25.2% (-40.5 to -6.1); p < 0.012). There was insufficient power for this analysis in blacks. In conclusion, in whites and South Asians the C allele of the Thr715Pro P-selectin polymorphism is associated with lower sP-selectin levels. Lower levels of sP-selectin were not accounted for by this polymorphism in blacks, in whom the C allele was very rare.

Original languageEnglish (US)
Pages (from-to)1060-1065
Number of pages6
JournalThrombosis and Haemostasis
Volume92
Issue number5
DOIs
StatePublished - Nov 1 2004

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P-Selectin
Population
Genes
Alleles
Hormone Replacement Therapy
Oral Contraceptives
Ethnic Groups
England
Coronary Disease
Cardiovascular Diseases
Stroke
Genotype
Hypertension
Lipids
Drug Therapy

Keywords

  • Cardiovascular disease
  • Ethnicity
  • Inflammation
  • Polymorphism
  • sP-selectin

ASJC Scopus subject areas

  • Hematology

Cite this

Association between the Thr715Pro P-selectin gene polymorphism and soluble P-selectin levels in a multiethnic population in South London. / Miller, Michelle A.; Kerry, Sally M.; Dong, Yanbin; Strazzullo, Pasquale; Cappuccio, Francesco P.

In: Thrombosis and Haemostasis, Vol. 92, No. 5, 01.11.2004, p. 1060-1065.

Research output: Contribution to journalArticle

Miller, Michelle A. ; Kerry, Sally M. ; Dong, Yanbin ; Strazzullo, Pasquale ; Cappuccio, Francesco P. / Association between the Thr715Pro P-selectin gene polymorphism and soluble P-selectin levels in a multiethnic population in South London. In: Thrombosis and Haemostasis. 2004 ; Vol. 92, No. 5. pp. 1060-1065.
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