Association between Treatment for Localized Prostate Cancer and Mental Health Outcomes

Amy N. Luckenbaugh; Christopher J.D. Wallis; Li Ching Huang; Daniela Wittmann; Zachary Klaassen; Zighuo Zhao; Tatsuki Koyama; Aaron A. Laviana; Ralph Conwill; Michael Goodman; Ann S. Hamilton; Xiao Cheng Wu; Lisa E. Paddock; Antoinette Stroup; Matthew R. Cooperberg; Mia Hashibe; Brock B. O’Neil; Sherrie H. Kaplan; Sheldon Greenfield; Karen E. Hoffman; David F. Penson; Daniel A. Barocas

doi:10.1097/JU.0000000000002370

Association between Treatment for Localized Prostate Cancer and Mental Health Outcomes

Amy N. Luckenbaugh, Christopher J.D. Wallis, Li Ching Huang, Daniela Wittmann, Zachary Klaassen, Zighuo Zhao, Tatsuki Koyama, Aaron A. Laviana, Ralph Conwill, Michael Goodman, Ann S. Hamilton, Xiao Cheng Wu, Lisa E. Paddock, Antoinette Stroup, Matthew R. Cooperberg, Mia Hashibe, Brock B. O’Neil, Sherrie H. Kaplan, Sheldon Greenfield, Karen E. HoffmanDavid F. Penson, Daniel A. Barocas

Urologic Surgery

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Results: A total of 2,742 men (median [quartiles] age 64 [59e70]) met inclusion criteria. Baseline depressive symptoms, as measured by the CES-D, were low (median 4, quartiles 1e8) without differences between groups. We found no effect of treatment modality on depressive symptoms (p[0.78), though older age, poorer health, being unmarried and baseline CES-D score were associated with declines in mental health. There was no clinically meaningful association between treatment modality and scores for either emotional well-being (p[0.81) or energy/fatigue (p[0.054). Conclusions: This prospective, population-based cohort study of men with localized prostate cancer showed no clinically important differences in mental health outcomes including depressive symptoms, emotional well-being, and energy/fatigue according to the treatment received (surgery, radiotherapy, or surveillance). However, we identified a number of characteristics associated with worse mental health outcomes including: older age, poorer health, being unmarried, and baseline CES-D score which may allow for early identification of patients most at risk of these outcomes following treatment.

Original language	English (US)
Pages (from-to)	1029-1037
Number of pages	9
Journal	Journal of Urology
Volume	207
Issue number	5
DOIs	https://doi.org/10.1097/JU.0000000000002370
State	Published - May 1 2022

Keywords

mental health
prostatic neoplasms
quality of life

ASJC Scopus subject areas

Urology

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10.1097/JU.0000000000002370

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Luckenbaugh, A. N., Wallis, C. J. D., Huang, L. C., Wittmann, D., Klaassen, Z., Zhao, Z., Koyama, T., Laviana, A. A., Conwill, R., Goodman, M., Hamilton, A. S., Wu, X. C., Paddock, L. E., Stroup, A., Cooperberg, M. R., Hashibe, M., O’Neil, B. B., Kaplan, S. H., Greenfield, S., ... Barocas, D. A. (2022). Association between Treatment for Localized Prostate Cancer and Mental Health Outcomes. Journal of Urology, 207(5), 1029-1037. https://doi.org/10.1097/JU.0000000000002370

Luckenbaugh, AN, Wallis, CJD, Huang, LC, Wittmann, D, Klaassen, Z, Zhao, Z, Koyama, T, Laviana, AA, Conwill, R, Goodman, M, Hamilton, AS, Wu, XC, Paddock, LE, Stroup, A, Cooperberg, MR, Hashibe, M, O’Neil, BB, Kaplan, SH, Greenfield, S, Hoffman, KE, Penson, DF & Barocas, DA 2022, 'Association between Treatment for Localized Prostate Cancer and Mental Health Outcomes', Journal of Urology, vol. 207, no. 5, pp. 1029-1037. https://doi.org/10.1097/JU.0000000000002370

@article{8f5a41888d754041a6607bc3fe1c8c44,

title = "Association between Treatment for Localized Prostate Cancer and Mental Health Outcomes",

abstract = "Results: A total of 2,742 men (median [quartiles] age 64 [59e70]) met inclusion criteria. Baseline depressive symptoms, as measured by the CES-D, were low (median 4, quartiles 1e8) without differences between groups. We found no effect of treatment modality on depressive symptoms (p[0.78), though older age, poorer health, being unmarried and baseline CES-D score were associated with declines in mental health. There was no clinically meaningful association between treatment modality and scores for either emotional well-being (p[0.81) or energy/fatigue (p[0.054). Conclusions: This prospective, population-based cohort study of men with localized prostate cancer showed no clinically important differences in mental health outcomes including depressive symptoms, emotional well-being, and energy/fatigue according to the treatment received (surgery, radiotherapy, or surveillance). However, we identified a number of characteristics associated with worse mental health outcomes including: older age, poorer health, being unmarried, and baseline CES-D score which may allow for early identification of patients most at risk of these outcomes following treatment.",

keywords = "mental health, prostatic neoplasms, quality of life",

author = "Luckenbaugh, {Amy N.} and Wallis, {Christopher J.D.} and Huang, {Li Ching} and Daniela Wittmann and Zachary Klaassen and Zighuo Zhao and Tatsuki Koyama and Laviana, {Aaron A.} and Ralph Conwill and Michael Goodman and Hamilton, {Ann S.} and Wu, {Xiao Cheng} and Paddock, {Lisa E.} and Antoinette Stroup and Cooperberg, {Matthew R.} and Mia Hashibe and O{\textquoteright}Neil, {Brock B.} and Kaplan, {Sherrie H.} and Sheldon Greenfield and Hoffman, {Karen E.} and Penson, {David F.} and Barocas, {Daniel A.}",

note = "Funding Information: Support: This work was supported by the Agency for Healthcare Research and Quality (1R01HS019356, 1R01HS022640, R01CA230352); the Patient-Centered Outcomes Research Institute (CE-12-11-4667); and the National Cancer Institute (NIH/NCI grant 5T32CA106183). Data management was facilitated by Vanderbilt University{\textquoteright}s Research Electronic Data Capture (REDCap) system, which is supported by the Vanderbilt Institute for Clinical and Translational Research grant (UL1TR000011 from NCATS/NIH). The funders had no role in the study design, data collection, and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2022 by AMERICAN UROLOGICAL ASSOCIATION EDUCATION AND RESEARCH, INC.",

year = "2022",

month = may,

day = "1",

doi = "10.1097/JU.0000000000002370",

language = "English (US)",

volume = "207",

pages = "1029--1037",

journal = "Investigative Urology",

issn = "0022-5347",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Association between Treatment for Localized Prostate Cancer and Mental Health Outcomes

AU - Luckenbaugh, Amy N.

AU - Wallis, Christopher J.D.

AU - Huang, Li Ching

AU - Wittmann, Daniela

AU - Klaassen, Zachary

AU - Zhao, Zighuo

AU - Koyama, Tatsuki

AU - Laviana, Aaron A.

AU - Conwill, Ralph

AU - Goodman, Michael

AU - Hamilton, Ann S.

AU - Wu, Xiao Cheng

AU - Paddock, Lisa E.

AU - Stroup, Antoinette

AU - Cooperberg, Matthew R.

AU - Hashibe, Mia

AU - O’Neil, Brock B.

AU - Kaplan, Sherrie H.

AU - Greenfield, Sheldon

AU - Hoffman, Karen E.

AU - Penson, David F.

AU - Barocas, Daniel A.

N1 - Funding Information: Support: This work was supported by the Agency for Healthcare Research and Quality (1R01HS019356, 1R01HS022640, R01CA230352); the Patient-Centered Outcomes Research Institute (CE-12-11-4667); and the National Cancer Institute (NIH/NCI grant 5T32CA106183). Data management was facilitated by Vanderbilt University’s Research Electronic Data Capture (REDCap) system, which is supported by the Vanderbilt Institute for Clinical and Translational Research grant (UL1TR000011 from NCATS/NIH). The funders had no role in the study design, data collection, and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2022 by AMERICAN UROLOGICAL ASSOCIATION EDUCATION AND RESEARCH, INC.

PY - 2022/5/1

Y1 - 2022/5/1

N2 - Results: A total of 2,742 men (median [quartiles] age 64 [59e70]) met inclusion criteria. Baseline depressive symptoms, as measured by the CES-D, were low (median 4, quartiles 1e8) without differences between groups. We found no effect of treatment modality on depressive symptoms (p[0.78), though older age, poorer health, being unmarried and baseline CES-D score were associated with declines in mental health. There was no clinically meaningful association between treatment modality and scores for either emotional well-being (p[0.81) or energy/fatigue (p[0.054). Conclusions: This prospective, population-based cohort study of men with localized prostate cancer showed no clinically important differences in mental health outcomes including depressive symptoms, emotional well-being, and energy/fatigue according to the treatment received (surgery, radiotherapy, or surveillance). However, we identified a number of characteristics associated with worse mental health outcomes including: older age, poorer health, being unmarried, and baseline CES-D score which may allow for early identification of patients most at risk of these outcomes following treatment.

AB - Results: A total of 2,742 men (median [quartiles] age 64 [59e70]) met inclusion criteria. Baseline depressive symptoms, as measured by the CES-D, were low (median 4, quartiles 1e8) without differences between groups. We found no effect of treatment modality on depressive symptoms (p[0.78), though older age, poorer health, being unmarried and baseline CES-D score were associated with declines in mental health. There was no clinically meaningful association between treatment modality and scores for either emotional well-being (p[0.81) or energy/fatigue (p[0.054). Conclusions: This prospective, population-based cohort study of men with localized prostate cancer showed no clinically important differences in mental health outcomes including depressive symptoms, emotional well-being, and energy/fatigue according to the treatment received (surgery, radiotherapy, or surveillance). However, we identified a number of characteristics associated with worse mental health outcomes including: older age, poorer health, being unmarried, and baseline CES-D score which may allow for early identification of patients most at risk of these outcomes following treatment.

KW - mental health

KW - prostatic neoplasms

KW - quality of life

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U2 - 10.1097/JU.0000000000002370

DO - 10.1097/JU.0000000000002370

M3 - Article

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AN - SCOPUS:85128250964

SN - 0022-5347

VL - 207

SP - 1029

EP - 1037

JO - Investigative Urology

JF - Investigative Urology

IS - 5

ER -

Association between Treatment for Localized Prostate Cancer and Mental Health Outcomes

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