Association between Treatment for Localized Prostate Cancer and Mental Health Outcomes

Amy N. Luckenbaugh, Christopher J.D. Wallis, Li Ching Huang, Daniela Wittmann, Zachary Klaassen, Zighuo Zhao, Tatsuki Koyama, Aaron A. Laviana, Ralph Conwill, Michael Goodman, Ann S. Hamilton, Xiao Cheng Wu, Lisa E. Paddock, Antoinette Stroup, Matthew R. Cooperberg, Mia Hashibe, Brock B. O’Neil, Sherrie H. Kaplan, Sheldon Greenfield, Karen E. HoffmanDavid F. Penson, Daniel A. Barocas

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Results: A total of 2,742 men (median [quartiles] age 64 [59e70]) met inclusion criteria. Baseline depressive symptoms, as measured by the CES-D, were low (median 4, quartiles 1e8) without differences between groups. We found no effect of treatment modality on depressive symptoms (p[0.78), though older age, poorer health, being unmarried and baseline CES-D score were associated with declines in mental health. There was no clinically meaningful association between treatment modality and scores for either emotional well-being (p[0.81) or energy/fatigue (p[0.054). Conclusions: This prospective, population-based cohort study of men with localized prostate cancer showed no clinically important differences in mental health outcomes including depressive symptoms, emotional well-being, and energy/fatigue according to the treatment received (surgery, radiotherapy, or surveillance). However, we identified a number of characteristics associated with worse mental health outcomes including: older age, poorer health, being unmarried, and baseline CES-D score which may allow for early identification of patients most at risk of these outcomes following treatment.

Original languageEnglish (US)
Pages (from-to)1029-1037
Number of pages9
JournalJournal of Urology
Issue number5
StatePublished - May 1 2022


  • mental health
  • prostatic neoplasms
  • quality of life

ASJC Scopus subject areas

  • Urology


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