Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population

M. P.L. Reddy, H. Wang, S. Liu, B. Bode, J. C. Reed, R. D. Steed, S. W. Anderson, L. Steed, D. Hopkins, Jin-Xiong She

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

The present study was conducted to assess genetic associations for type 1 diabetes (T1D) reported in previous genome-wide association studies (GWAS). A total of 21 previously reported single-nucleotide polymorphisms (SNPs) were genotyped by TaqMan assays in 1434 Caucasian T1D patients and 1864 normal controls from Georgia. Analysis of the samples identified 18 SNPs (PTPN22, INS, IFIH1, SH2B3, ERBB3, CTLA4, C14orf181, CTSH, CLEC16A, CD69, ITPR3, C6orf173, SKAP2, PRKCQ, RNLS, IL27, SIRPG and CTRB2) with putative association.

Original languageEnglish (US)
Pages (from-to)208-212
Number of pages5
JournalGenes and Immunity
Volume12
Issue number3
DOIs
StatePublished - Apr 2011

Keywords

  • T1D
  • candidate genes
  • genetics

ASJC Scopus subject areas

  • Immunology
  • Genetics
  • Genetics(clinical)

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    Reddy, M. P. L., Wang, H., Liu, S., Bode, B., Reed, J. C., Steed, R. D., Anderson, S. W., Steed, L., Hopkins, D., & She, J-X. (2011). Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population. Genes and Immunity, 12(3), 208-212. https://doi.org/10.1038/gene.2010.70