Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population

M. P.L. Reddy, H. Wang, S. Liu, B. Bode, J. C. Reed, R. D. Steed, S. W. Anderson, L. Steed, D. Hopkins, Jin-Xiong She

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The present study was conducted to assess genetic associations for type 1 diabetes (T1D) reported in previous genome-wide association studies (GWAS). A total of 21 previously reported single-nucleotide polymorphisms (SNPs) were genotyped by TaqMan assays in 1434 Caucasian T1D patients and 1864 normal controls from Georgia. Analysis of the samples identified 18 SNPs (PTPN22, INS, IFIH1, SH2B3, ERBB3, CTLA4, C14orf181, CTSH, CLEC16A, CD69, ITPR3, C6orf173, SKAP2, PRKCQ, RNLS, IL27, SIRPG and CTRB2) with putative association.

Original languageEnglish (US)
Pages (from-to)208-212
Number of pages5
JournalGenes and Immunity
Volume12
Issue number3
DOIs
StatePublished - Apr 1 2011

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Southeastern United States
Genome-Wide Association Study
Type 1 Diabetes Mellitus
Single Nucleotide Polymorphism
Interleukin-27
Population

Keywords

  • T1D
  • candidate genes
  • genetics

ASJC Scopus subject areas

  • Immunology
  • Genetics
  • Genetics(clinical)

Cite this

Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population. / Reddy, M. P.L.; Wang, H.; Liu, S.; Bode, B.; Reed, J. C.; Steed, R. D.; Anderson, S. W.; Steed, L.; Hopkins, D.; She, Jin-Xiong.

In: Genes and Immunity, Vol. 12, No. 3, 01.04.2011, p. 208-212.

Research output: Contribution to journalArticle

Reddy, MPL, Wang, H, Liu, S, Bode, B, Reed, JC, Steed, RD, Anderson, SW, Steed, L, Hopkins, D & She, J-X 2011, 'Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population', Genes and Immunity, vol. 12, no. 3, pp. 208-212. https://doi.org/10.1038/gene.2010.70
Reddy, M. P.L. ; Wang, H. ; Liu, S. ; Bode, B. ; Reed, J. C. ; Steed, R. D. ; Anderson, S. W. ; Steed, L. ; Hopkins, D. ; She, Jin-Xiong. / Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population. In: Genes and Immunity. 2011 ; Vol. 12, No. 3. pp. 208-212.
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